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research Association of Lifelong Intake of Barley Diet with Healthy Aging: Changes in Physical and Cognitive Functions and Intestinal Microbiome in Senescence-Accelerated Mouse-Prone 8 (SAMP8)

18 citations , August 2019 in “Nutrients”

In this study, lifelong barley intake in SAMP8 mice was associated with extended lifespan, improved aging-related phenotypes, and beneficial shifts in the intestinal microbiome.

research Exploring the impact of acetylsalicylic acid and conditioned medium obtained from mesenchymal cells, individually and in combination, on cognitive function, histological changes, and oxidant–antioxidant balance in male rats with hippocampal injury

3 citations , September 2024 in “Brain and Behavior”

This study found that combining ASA with conditioned medium from adipose tissue-derived MSCs may offer a promising approach for protecting against hippocampal injuries, suggesting potential synergistic therapeutic benefits that merit further investigation.

research Significant effects of mild endogenous hormonal changes in humans: considerations for low-dose testing.

30 citations , March 2001 in “Environmental Health Perspectives”

This review explores the significant impacts of hormonal changes within normal physiological ranges and suggests examining low-dose effects from chemicals disrupting hormonal activity; it presents no new clinical results.

research Advances in Knowledge of Androgens: How Intentional and Accidental Neurosteroid Changes Inform Us of Their Action and Role

December 2020 in “Current Sexual Health Reports”

This review discusses the role of neurosteroids and androgens throughout different life stages, noting the potential disruptions caused by 5α-reductase inhibitors like finasteride, but no new clinical results are reported.

research Finasteride

June 2021 in “Reactions Weekly”

Finasteride caused serious side effects and led to six suicides.

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Community Join

5 / 147 results

community Finasteride, Neurosteroids, and Neuroplasticity - have you noticed cognitive shifts or have you continued growing?

in Basic Questions 201 upvotes 3 months ago

The conversation discusses concerns about potential cognitive and emotional effects of finasteride, with the original poster planning to monitor their cognitive performance while using the treatment. A user responds that most people do not experience cognitive shifts, though some report subtle changes.

community Switching from Finasteride to RU58841?

in General 168 upvotes 1 year ago

The user experienced severe side effects from finasteride, including cognitive and sexual issues, despite its effectiveness for hair growth. They are considering switching to RU58841 and seek insights from others who have made a similar change.

community Why is sexual functioning the main concern? Fin/dut can affect cognition and mood, arguably being more important

in Finasteride/Dutasteride 65 upvotes 5 months ago

Finasteride and dutasteride can affect sexual function, cognition, and mood. Alternatives like minoxidil, pyrilutamide, and alfatradiol have varied effectiveness and side effects.

community Experiencing cognitive effects while on Dutasteride

5 upvotes 3 weeks ago

The user experienced fatigue, brain fog, and dizziness after taking Dutasteride for hair loss, suspecting it might be a side effect. They plan to consult a doctor and get blood work done, while others in the conversation discuss potential cognitive effects and compare Dutasteride to Finasteride.

community Stop Complaining about Creatine. You're just fixated on shedding.

73 upvotes 1 year ago

Creatine is unlikely to cause hair loss as it does not raise DHT levels. Hair loss is more likely due to genetics, medications, or lifestyle changes.

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Learn

2 / 2 results

learn Finasteride

Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

Finasteride Results Timeline: How Long It Takes to Work, Shedding Phases, and Expected Outcomes Trial data and community reports both put the first visible changes on finasteride at roughly 3 to 6 months, with the clearest results between 6 and 12 months; some people report an early increase in shedding, but how often this happens has not been measured. The benefit lasts only while the drug is taken, it is prescription-only, and its labels warn of sexual side effects that have continued after stopping in some men, of depression and suicidal thoughts, and of breast and semen changes; some former users also report anxiety and cognitive complaints (see "Is finasteride safe?").

learn Dutasteride

5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

Clinics

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