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This study synthesizes knowledge of how dendritic cell signals, epithelial integrins, and fibroblast activity converge on TGF-β1 to maintain or disrupt skin healing, contrasting normal and fibrotic scar formation and suggesting possible integrin and immune-targeted treatments for skin fibrosis.

In this review, retinoids are highlighted as promising agents for promoting scarless skin regeneration by coordinating cellular and molecular processes that suppress fibrosis, enhance re-epithelialization, promote angiogenesis, and enable hair follicle formation, potentially advancing functional skin repair.

This narrative piece considers how epigenetic factors may influence the processes of skin wound healing, including hair follicle formation, but it presents no new experimental results.

In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.

This review explores fibroblast heterogeneity in the mammalian dermis and suggests potential therapeutic applications by targeting fibroblast subtypes, but reports no new experimental results.

This review discusses the role of peroxisome proliferator-activated receptors and their agonists in dermatology but reports no new clinical results.

This review discusses dermal white adipose tissue's roles in skin immunity, highlighting its antimicrobial function and interactions with other immune cells, but reports no new clinical results.

This study found that fibromodulin significantly reduces scar formation and boosts scar strength in rodent and porcine models, suggesting potential for FMOD-based therapies in cutaneous wound repair.

This study found that Tsukushi facilitates wound healing in mice by regulating macrophage function and myofibroblast differentiation.

Turning scar-forming cells into fat cells can reduce scarring.

This study found that extracellular vesicles derived from mesenchymal stem cells and umbilical cord blood plasma enhanced wound healing and reduced scar formation in mice, suggesting their potential as therapeutic agents for skin repair.

This study found that epidermal stem cell-specific Jag1 expression levels are crucial for effective wound healing and scar reduction, and porcine acellular dermal matrix treatment enhances this process in mice by boosting Notch/Jagged1 signaling.

This study suggests that CTHRC1, a protein expressed in cardiac fibroblasts, may improve wound repair and prevent cardiac rupture after myocardial infarction by activating a specific signaling pathway.

This study identified CD201+ fibroblast progenitors in mouse skin that regulate wound healing through differentiation into specialized cell types, with retinoic acid and hypoxia influencing this process.

This study developed a composite hydrogel that delivered multiple proteins, enhancing skin wound healing by accelerating closure and promoting hair follicle regeneration.

This review highlights that the RNA modification N⁶-methyladenosine (m⁶A) plays a crucial role in regulating wound healing and tissue remodeling, with dysregulation contributing to complications in chronic wounds, such as diabetic ulcers and burn injuries, through mechanisms like impaired angiogenesis and increased oxidative stress.

E13 fetal mouse fibroblast vesicles may help reduce scarring.

This narrative review examines advancements in regenerative aesthetic medicine, focusing on injectable modalities like PRP, polynucleotides, and exosomes, but highlights the need for more robust evidence and standardization in clinical applications.

This review suggests that the mTOR signaling pathway may play a significant role in hair follicle health by influencing the effects of Vitamin D receptor deficiency, potentially contributing to hair follicle damage and related hair loss conditions.

This study found that D-peptide crosslinked MAP hydrogel accelerated material degradation in vivo but significantly enhanced skin regeneration, suggesting an adaptive immune response can drive regenerative healing even with rapid scaffold breakdown.

This review updates the understanding of fibroblast heterogeneity in wound healing, discussing advancements in fibroblast roles and potential therapies, but it reports no new clinical results.

This article discusses the staging of central centrifugal cicatricial alopecia in women of African descent and reports no new clinical results.

This study found that glioblastoma cancer stem cells avoid immune suppression by downregulating TLR4, and restoring TLR4 signaling may reduce tumor growth and self-renewal.

This study observed that transgenic mice with overexpression of HE4 developed keratitis and severe corneal opacity, suggesting that HE4 may significantly influence keratopathy and inflammatory responses in the eye.

This study found that toll-like receptor 9 plays a previously unrecognized role in sensing skin injury and influencing tissue repair and regeneration in adult mice by modulating γδT cell migration.

Certain hairstyles can cause scalp diseases, smoking is linked to hair loss, 5% minoxidil foam is effective for hair loss treatment, and various factors influence wound healing and hair growth.

This study suggests that dermal adipocytes might play a key role in skin aging due to their transformation into fibrotic structures in chronically photo-damaged skin.

This study found that dermal stem cells from granulation tissue promoted wound healing and reduced fibrosis in a combined radiation and skin wound mouse model.

In this study, researchers found that topical application of the diabetes medication Sitagliptin in mice accelerates hair follicle regeneration and reduces fibrosis, suggesting it could be repurposed to treat hair loss conditions like alopecia.

This study found that αvβ6 integrin inhibits keratinocyte proliferation during wound healing and hair regeneration, suggesting its downregulation may enhance recovery and influence epidermal stem cell behavior.