January 2010 in “Pharmacy Today” This study found that collagen and its compound may have antioxidant effects and reduce melanin in guinea pigs, while increasing skin moisture and hydroxyproline content in mice.
5 citations
,
January 2016 in “Hair therapy & transplantation” In this study, miliacin combined with polar lipids significantly stimulated IGF1 production, increased the renewal of keratinocytes, and enhanced collagen thickness in a hair follicle model.
3 citations
,
March 2022 in “Polymers” This study found that applying glycosaminoglycans fractions from ascidian tunics stimulated human follicle dermal papilla cell proliferation and, when used on mice hair for 28 days, produced a hair growth effect comparable to Minoxidil.
1 citations
,
May 2024 in “Journal of Dermatological Science” In this study, KC-AD-MSCs were found to increase COL7 deposition and anchoring fibril formation at the dermal-epidermal junction in a RDEB mouse model, suggesting potential for improving skin integrity in recessive dystrophic epidermolysis bullosa patients.
October 2022 in “ACS Applied Materials & Interfaces” This study reports that the newly developed SA-Ca(II) hydrogel has tunable mechanical properties, high biocompatibility, and potential applications in wearable protections and stimuli-responsive electronics.
This research evaluated the wound healing potential of NIMO-CH, a cellulose hydrogel with indigenous microorganisms, in ICR mice and found complete wound closure with hair growth by day 18-20, suggesting it could be a viable alternative for wound care.
69 citations
,
October 2013 in “Tissue Engineering Part A” This study found that using a keratin hydrogel scaffold as a filler in collagen nerve conduits significantly improved nerve regeneration and motor recovery in Macaca fascicularis monkeys compared to saline.
2 citations
,
February 2021 in “IONTech.” This study found that a 5% concentration of snail mucus shampoo was most effective in promoting hair growth in rabbits compared to lower concentrations.
1 citations
,
February 2026 in “ACS Nano” This study developed the TLMG hydrogel, a seamless in situ biointerface platform, demonstrating robust adhesion, high conductivity, and therapeutic effects for intelligent wound management in complex animal models and human tests, indicating its promise for integrated bioelectronic medicine.
3 citations
,
September 2023 in “Advanced science” Researchers demonstrated that a new vaccine platform using antigen-loaded hydrogels enhanced humoral immune responses in mice, producing stronger antigen-specific antibody levels compared to the conventional adjuvant Alum, and offering promising protective capabilities against influenza virus.
January 2004 in “uO Research (University of Ottawa)” This study found that overexpression of Claudin 6 in mice led to incomplete epidermal formation and hair abnormalities, suggesting its crucial role in skin differentiation and hair follicle development.
February 2023 in “Medicine in novel technology and devices” This study found that microneedle delivery of Polygonum multiflorum extract led to earlier pigmentation and hair regrowth in mice with androgenetic alopecia.
4 citations
,
October 2024 in “BMC Oral Health” This review suggests that PRF may be a promising alternative treatment for oral mucosal lesions, but further research is needed to confirm its long-term effectiveness and standardize preparation protocols.
6 citations
,
September 2024 in “Plant Cell & Environment” This study found that in Arabidopsis root hairs, mild chitosan treatment triggered callose deposition and slowed growth, while a higher concentration inhibited growth without callose deposition, indicating different responses based on chitosan concentration.
May 2026 in “Iranian journal of pharmaceutical research” This study found that HAMA hydrogels promote faster healing of skin wounds in mice by enhancing the accumulation of anti-inflammatory macrophages and increasing type III collagen in the local wound environment.
February 2026 in “International Journal of Molecular Sciences” In this study, the researchers found that cholinergic signaling via M4 muscarinic receptors influences hair growth, with enhanced elongation observed upon activation with bethanechol, highlighting its potential role in hair biology using mouse models.
March 2025 in “Dental Journal (Majalah Kedokteran Gigi)” This study developed a biodegradable gelatin and chitosan hemostatic sponge, enhanced with pomegranate peel extract, for dental applications, highlighting its effective antibacterial properties, improved blood absorption, and reduced clotting time, suggesting potential for use in clinical dental and wound care procedures.
21 citations
,
December 2015 in “European journal of cell biology” In this study, researchers demonstrated that follicular tight junctions in porcine skin form a barrier to nanoparticle penetration, particularly in upper regions, which supports its use as a model for human skin.
2 citations
,
May 2024 in “European journal of medical research” This study found that a conditioned medium from human umbilical cord mesenchymal stem cells cultured in a gelatin sponge significantly enhanced hair growth and promoted skin angiogenesis in a mouse model, more effectively than a monolayer culture.
19 citations
,
May 2020 in “Cells” This study found that 5% primed conditioned medium from human umbilical cord blood-derived mesenchymal stromal cells significantly improved hair density, thickness, and growth rate in patients with androgenetic alopecia.
January 2006 in “Chinese Journal of Dermatology” In this study, researchers found that hair follicle-like structures can be generated from collagen/chitosan porous scaffolds implanted with mouse hair follicle cells in vitro.
January 2017 in “DR-NTU (Nanyang Technological University)” This study observed that keratin sponges showed comparable biocompatibility to a commercial positive control in mice, but keratin gels had slightly inferior biocompatibility.
10 citations
,
September 1997 in “Molecular carcinogenesis” This study found that mirex and TPA promote papilloma formation in CD-1 mouse skin through distinct populations of mutant Ha-ras cells, resulting in additive tumor yields.
150 citations
,
May 1993 in “The journal of cell biology/The Journal of cell biology” This study suggests that mNotch expression plays a significant role in hair follicle differentiation and cell fate selection within the follicle during development.
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, mouse sebaceous glands were found to require nerves for growth during active hair cycles, suggesting a nerve-dependent sebaceous gland cycle coordinated with hair growth.
2 citations
,
March 2023 in “European Polymer Journal” This study developed multifunctional nanofiber wound dressings that significantly reduced bacteria and promoted healing in a mouse wound model by incorporating antibacterial and growth-promoting agents.
2 citations
,
December 2023 in “Advanced science” This review discusses the roles and mechanisms of glycosaminoglycans in wound healing and presents challenges and potential applications for GAG-based biomaterials without reporting new experimental results.
January 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study demonstrates that collagen XVII is crucial for normal glomerular development, is present in normal colon epithelia, and plays a role in carcinogenesis in colorectal and squamous cell cancers.
June 2022 in “Scientific Reports” This study found that prevelex coatings on microwell array devices enhanced the formation of uniform cell spheroids and enabled the development of hair follicles in tissue engineering applications.