A Human Hair Keratin Hydrogel Scaffold Enhances Median Nerve Regeneration in Nonhuman Primates: An Electrophysiological and Histological Study

October 2013 in “ Tissue Engineering Part A ”

Lauren A. Pace, Johannes F. Plate, Sandeep Mannava, Jonathan Barnwell, L. Andrew Koman, Zhongyu Li, Thomas L. Smith, Mark Van Dyke

keratin hydrogel NeuraGen collagen conduit nerve regeneration median nerve nerve conduit biomaterial hydrogel peripheral nerve regeneration NeuraGen

Studysummary This study found that using a keratin hydrogel scaffold as a filler in collagen nerve conduits significantly improved nerve regeneration and motor recovery in Macaca fascicularis monkeys compared to saline.

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research Mechanical and Biological Properties of Keratose Biomaterials

140 citations , August 2011 in “Biomaterials”

This study observed that keratose, derived from human hair, integrated well in mouse tissue and remodeled with collagen, suggesting potential as a non-toxic biomaterial for regenerative applications.

research The Use of Keratin Biomaterials Derived from Human Hair for the Promotion of Rapid Regeneration of Peripheral Nerves

309 citations , October 2007 in “Biomaterials”

This study found that a biomaterial gel made from human hair keratins facilitated nerve regeneration in an animal model, potentially matching the effectiveness of traditional autografts.