Wound Healing Efficacy of Cellulose Hydrogel on ICR Mice: A Morphoanatomical, Histological, and Genomic Study

September 2024

Alessandra Almeida Castro, Alvin G Domingo, Jayson F Cariaga, Francis A Gamboa, Aira Cassandra Castro, Aira Nadine Pascua, Jimmbeth Zenila P. Fabia, Peter James Gann, Bjorn S. Santos, Shirley C. Agrupis

cellulose hydrogel NIMO-CH Lacticaseibacillus paracasei DuoDERM wound healing hair growth sodA gene gsiC gene cellulose gel

TLDR NIMO-CH hydrogel effectively heals wounds with minimal scarring and promotes hair growth.

This study investigated the wound healing efficacy of NIMO-CH, a cellulose hydrogel derived from nipa fronds and enriched with Lacticaseibacillus paracasei BCRC-16100, on ICR mice with excisional wounds. The treatments compared were no treatment, NIMO-CH, and DuoDERM. Both NIMO-CH and DuoDERM achieved 100% wound closure, with NIMO-CH-treated wounds showing complete healing with hair growth by days 18-20, while untreated wounds healed by day 20. Minimal scarring was observed in both NIMO-CH and DuoDERM groups. Histological analysis showed similar healing processes, and genome sequencing identified genes sodA and gsiC in Lacticaseibacillus paracasei BCRC-16100, which are important for wound healing. The results suggest that NIMO-CH could be an effective alternative for wound care applications.

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