Wound Healing Efficacy of Cellulose Hydrogel on ICR Mice: A Morphoanatomical, Histological, and Genomic Study
September 2024
🚨 The study is moderately relevant as it involves wound healing in mice, which can be related to human wound healing and hair regrowth, but it does not directly address hair loss, alopecia, or scalp health.
TLDR NIMO-CH hydrogel effectively heals wounds with minimal scarring and promotes hair growth.
This study investigated the wound healing efficacy of NIMO-CH, a cellulose hydrogel derived from nipa fronds and enriched with Lacticaseibacillus paracasei BCRC-16100, on ICR mice with excisional wounds. The treatments compared were no treatment, NIMO-CH, and DuoDERM. Both NIMO-CH and DuoDERM achieved 100% wound closure, with NIMO-CH-treated wounds showing complete healing with hair growth by days 18-20, while untreated wounds healed by day 20. Minimal scarring was observed in both NIMO-CH and DuoDERM groups. Histological analysis showed similar healing processes, and genome sequencing identified genes sodA and gsiC in Lacticaseibacillus paracasei BCRC-16100, which are important for wound healing. The results suggest that NIMO-CH could be an effective alternative for wound care applications.
