Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This article reviews skin toxicity classifications and management in patients undergoing molecularly targeted therapy, noting significant dermatotropic side effects associated with Epidermal Growth Factor Receptor Inhibitors.

This study found that transient mtDNA double strand breaks in mice accelerated aging in certain tissues through increased reactive oxygen species, independent of p21/p53 pathway mediation.

This study found that oral minipulse therapy with betamethasone may effectively promote hair regrowth in alopecia areata while causing fewer severe side effects compared to traditional pulse therapy.

This study identified melatonin as a potential treatment for rosacea and Alzheimer's disease, suggesting it may help by modulating inflammatory and vascular signaling pathways.

This study found that a single 2 ml injection of TEEV every 4 weeks offers similar beneficial effects with fewer side effects compared to injecting the same dose every 2 weeks in postmenopausal women.

This study found that ethosome-loaded minoxidil and tocopherol acetate improved hair regeneration and regulated the microenvironment around hair follicles better than commercial minoxidil in androgenic alopecia model mice, showing promise as a treatment strategy.

Tremella fuciformis Berk helps protect hair from stress-related damage.

This study reported that ZSYY001, a nanoparticle formulation of polymeric micellar paclitaxel, showed promising antitumor activity and was safe and well-tolerated in preclinical models and a phase I trial, without acute hypersensitivity reactions at doses up to 390 mg/m².

This study found that a specific gene mutation was identified in a family with monilethrix, and treatment with 5% minoxidil liniment improved hair quality in the proband without adverse events.

This study found that Mdm2 is critical for limiting p53 activity to maintain normal stem cell function in mouse skin, with impacts on tissue homeostasis and aging.

In this study, two methotrexate-loaded liquid crystal formulations for topical application showed immunomodulatory effects and induced skin changes in mice with imiquimod-induced psoriasis.

This study suggests that the testosterone analogs 7α-Methyltestosterone and 7α-Ethyltestosterone may offer promising androgenic, progestogenic, and anabolic properties for development as male contraceptives.

This study found that spraying melon plants with 0.1 mg·L–1 molybdenum significantly improved growth, photosynthetic characteristics, carbohydrate metabolism, and fruit quality under high-temperature stress, boosting fruit weight by 27.9% and yield per plant by 20.1% compared to untreated controls.

This study found that formulating raloxifene in nano-lipid carriers significantly enhanced its permeation and cytotoxicity against cancer cells compared to raw raloxifene.

In this institution-based randomized trial, oral betamethasone mini-pulse therapy for alopecia areata showed a faster therapeutic response compared to oral tofacitinib, as measured by trichoscopic changes and achievement of 50% hair regrowth.

This study found that the p.E402K mutation in the KRT86 gene is a hotspot in Chinese patients with monilethrix, and treatment with 5% topical minoxidil significantly improved hair density and quality.

This article suggests using nicotinamide and minoxidil as potassium channel activators to target solid tumors, but reports no new clinical results and calls for further research.

In this study, the size of vaginal prolapse was significantly linked to preoperative vaginal length and the length of vaginal excision following the Michigan four-wall sacrospinous suspension.

In this study, researchers presented a novel therapeutic approach for androgenetic alopecia combining AR-PROTAC degradation with regenerative strategies and evaluated the potential of GT20029 as a topical treatment, proposing a three-phase protocol and future research hypotheses.

This study developed microfluidics-based 3D microtumors to model minimal residual disease in ovarian cancer, highlighting their alignment with patient-derived MRD and response to a fatty acid oxidation inhibitor.

Enhancing Tregs can protect against alopecia areata.

In this study, autologous micrografting technology using auricular cartilage was reported to be safe and effective for improving knee function and reducing symptoms in patients with early-stage knee osteoarthritis over six months, but larger studies are needed to confirm these results.

This systematic review reported that both hair transplantation and topical minoxidil were associated with cosmetic improvement in patients with temporal triangular alopecia, but noted that the evidence is based on low-level studies and highlighted the need for higher-quality research, especially in pediatric populations.

This abstract reports on a presentation at a meeting that detailed the hair restoration of a patient with Norwood Class 5 pattern using 1,325 four-haired minigrafts, but it provides no clinical results.

In this study, ELE was found to protect against oxidative stress-induced testosterone reduction in TM3 Leydig cells by increasing testosterone synthesis and decreasing its conversion.

This study identified a new gene, mrp4, in mice, which suggests it may have a unique role in the growth and development of hair follicles in the ears and tails.

Melatonin helps broccoli roots produce anti-cancer compounds by controlling nitric oxide and hydrogen peroxide levels.

In this study, a combination of terbinafine and mitotane was used to treat a dog with pituitary-dependent hyperadrenocorticism and dermatophytosis, showing regrowth of hair and negative fungal cultures without detectable adverse effects.

Three molecular subtypes of advanced skin T-cell lymphoma were identified, with potential biomarkers for predicting treatment response and disease progression.

This case series reports that electrochemotherapy with intravenous bleomycin effectively resolved cutaneous mast cell tumors in four cats, showing no tumor recurrence during follow-up, except for new lesions in one cat, and minimal local toxicity.