Gene Detection in a Family With Monilethrix and Treatment With 5% Topical Minoxidil

    November 2022 in “ Skin research and technology ”
    Qingli Shen, Zhonghua Fu, Pengqiang Du, Jianbo Wang
    Studysummary This study found that the p.E402K mutation in the KRT86 gene is a hotspot in Chinese patients with monilethrix, and treatment with 5% topical minoxidil significantly improved hair density and quality.
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    Research cited in this study 10

    1. Gene Detection in a Family With Monilethrix and Treatment With 5% Topical Minoxidil Skin research and technology · 2022
    2. Autosomal Recessive Monilethrix: Novel Variants of the DSG4 Gene in Three Chinese Families Molecular genetics & genomic medicine · 2022
    3. Treatment of Monilethrix with Oral Minoxidil JAAD case reports · 2016
    4. Monilethrix: A Typical Case Report with Microscopic and Dermatoscopic Findings Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2015
    5. Mutation Detection of Type II Hair Cortex Keratin Gene KRT86 in a Chinese Han Family With Congenital Monilethrix Chinese Medical Journal · 2013
    6. Monilethrix Treated with Minoxidil International Journal of Immunopathology and Pharmacology · 2011
    7. A Missense Mutation in the Type II Hair Keratin hHb3 Is Associated with Monilethrix Journal of Medical Genetics · 2005
    8. Monilethrix: Mutational Hotspot in the Helix Termination Motif of the Human Hair Basic Keratin 6 Human Heredity · 2000
    9. A Mutational Hotspot in the 2B Domain of Human Hair Basic Keratin 6 (hHb6) in Monilethrix Patients Journal of Investigative Dermatology · 1998
    10. A New Mutation in the Type II Hair Cortex Keratin hHb1 Involved in the Inherited Hair Disorder Monilethrix Human Genetics · 1997