Proteomics and Transcriptomics Profiling Define Molecular Subtypes of Advanced Cutaneous T Cell Lymphoma and Prognostic Biomarkers

    July 2025 in “ Journal of Investigative Dermatology ”
    Shuyu Zhang, Zijian Guo, Wei Sun, Jing Liu
    TLDR Three molecular subtypes of advanced skin T-cell lymphoma were identified, with potential biomarkers for predicting treatment response and disease progression.
    This study investigates advanced cutaneous T-cell lymphomas, specifically mycosis fungoides (MF) and Sézary syndrome (SS), by performing proteomic and transcriptomic profiling on 33 skin biopsies. The research identifies three distinct molecular subtypes of advanced MF/SS, each with unique phenotypic characteristics related to intracellular signaling, energy metabolism, and extracellular matrix remodeling. These findings highlight the heterogeneity among patients and offer new insights into the disease's pathogenesis. Additionally, the study identifies potential biomarkers for predicting treatment response and disease progression, which were validated through immunohistochemical staining.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 19 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  43 upvotes 6 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Being Safe on Oral Minoxidil: tl;dr on the literature.

      in Research/Science  49 upvotes 1 year ago
      Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.

      community How do you use rosemary oil and peppermint oil?

      in Question  6 upvotes 6 years ago
      Rosemary oil and peppermint oil may promote hair growth and increase cutaneous blood flow, showing promise as treatments for androgenetic alopecia. Minoxidil 2% is also used for treating hair loss.

      community Scientific evidence for Peppermint & Rosemary oils + My Experience

      in Research/Science  114 upvotes 3 years ago
      Natural treatments for hair loss, specifically peppermint oil and rosemary oil; how they can be used as a supplementary or alternative treatment to pharmaceuticals such as finasteride and minoxidil; and the personal experience of the user Divallo, who has seen an increase in density and thickness after using these oils for around 2.5 years. The post also touches on the potential antifungal properties of the oils and their effects on cutaneous blood flow.

      community Not sure if fin is enough, still losing lots of hair

      in Finasteride/Dutasteride  6 upvotes 1 year ago
      The user has been on finasteride for 17 months to treat hair loss, with some improvement in the crown but still experiencing significant shedding. They are considering if finasteride alone is sufficient and are hesitant to use minoxidil due to a pre-existing condition, while another person suggests trying dutasteride.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  63 upvotes 2 years ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

    Similar Research

    5 / 1000+ results