Effect of Eurycoma Longifolia Extract on Testosterone Synthesis in TM3 Leydig Cells Under Oxidative Stress

July 2022 in “ Han'gug sigpum yeong'yang gwahag hoeji/Journal of the Korean society of food science and nutrition ”

Jae In Jung, Sangwon Eun, Jae Kyoung Lee, Young Ha Seo, Mun Hyoung Bae, Ryong Kim, Eun Ji Kim

Eurycoma longifolia testosterone TM3 Leydig cells oxidative stress steroidogenic enzymes StAR 3β-HSD CYP17A1 5α-reductase aromatase andropause Longjack Leydig cells 5-alpha reductase

TLDR Eurycoma longifolia extract may help increase testosterone levels and reduce andropause symptoms.

Eurycoma longifolia extract (ELE) has been shown to counteract oxidative stress-induced reductions in testosterone levels in TM3 Leydig cells by enhancing the expressions of steroidogenic enzymes (StAR, 3β-HSD, and CYP17A1) involved in testosterone synthesis and reducing the expressions of enzymes (5α-reductase and aromatase) that convert testosterone to other hormones. This suggests that ELE could be beneficial in alleviating andropause symptoms associated with low testosterone levels.

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