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Scientists identified and cloned specific keratin proteins in mouse hair.

In this study using a mouse model, researchers observed that topical nifedipine cream at 0.3% concentration promoted hair growth more effectively than 2% minoxidil solution, suggesting that nifedipine may have potential as a hair growth treatment.

This study presented a refined surgical protocol for a fetal mouse model that improves pregnancy success, reduces fetal loss, and allows for consistent phenotypic outcomes, enhancing research in scarless skin regeneration.

In this preclinical study, PA-011 derived from Periplaneta americana showed significant hair regrowth effects in androgenetic alopecia mouse models by inhibiting inflammation and oxidative stress, activating hair follicle stem cell proliferation, and normalizing skin microbiota, suggesting promise as an AGA treatment.

This study highlighted the effectiveness of HT-scCAT-seq as a tool for understanding gene regulation in single cells, offering insights into embryonic skin development and proposing a framework for exploring regulatory mechanisms in various biological and disease contexts.

This study found that dermal papilla cell-derived exosomes promote hair follicle regeneration during wound healing by enhancing fibroblast activity and activating the Wnt/β-catenin signaling pathway in mice.

In this study, Almet et al. (2023) compiled integrated single-cell RNA sequencing data from multiple mouse datasets to investigate how fibroblasts evolve during wound healing by examining changes in the extracellular matrix and signaling pathways.

This study does not report results but provides integrated single-cell RNA sequencing data from multiple mouse wound healing models, offering resources for studying fibroblast-driven changes in the extracellular matrix and signaling during the healing process.

This study found that overexpressing Rps14 in supporting cells promoted hair cell regeneration in the organ of Corti by facilitating cell proliferation and differentiation.

In this study, mouse hair follicle stem cells cultured in mouse embryonic fibroblast/keratinocyte serum-free medium exhibited the highest proliferative ability and stronger osteogenic differentiation potential, similar to hair follicle dermal papilla cells.

In this study, neonatal mouse mesenchymal cells showed hair-inducing capabilities, which were lost during in vitro propagation but could be partially restored through specific high-density culture methods.

This study reported that mSKPs and DMSCs share similarities in biological characteristics but exhibit distinct transcriptome profiles, with mSKPs being more immune-related and DMSCs more associated with differentiation and disease pathways.

This in vitro study suggests that Biofield Energy Healing Treatment may promote hair growth as evidenced by increased telogen formation in vibrissae hair follicle organ culture cells.

PTHrP is important for bone formation and may be targeted for osteoporosis treatment and longevity therapies.

This study found that altering CDK4 expression in mice affects the population of keratinocyte stem cells, suggesting a correlation with susceptibility to skin papillomas.

Mouse hair element patterns vary, making it unreliable for tracking time.

This study found that mimicking the XPD point mutation in mice resulted in trichothiodystrophy-like symptoms, supporting the role of basal transcription and DNA repair defects in the disease.

This review discusses the commonly observed pathological findings in progeroid mouse models and highlights the importance of understanding mouse strain backgrounds and progeria-related phenotypes for accurate pathology data interpretation.

In a transgenic mouse model, this study found that overexpression of keratin 16 in skin keratinocytes led to hyperkeratosis and increased EGF receptor signaling, altering skin cell behavior and structure.

This study developed an animal model that recreates alopecia areata by injecting healthy human skin grafts in immunocompromised mice with peripheral blood mononuclear cells enriched for NKG2D+ and CD56+ cells.

This study suggests that mouse keratin 6 isoforms, K6a and K6b, have overlapping but distinct expression profiles, differing notably in their expression in suprabasal cells and response to phorbol esters.

This study found that the angora mouse mutation prolongs the anagen phase, resulting in excessively long hair and follicular abnormalities, without involving circulating hair cycle factors.

This study found that the development and differentiation of Merkel cells in C57BL mouse embryos' dorsolateral skin are linked to tylotrich follicle formation rather than to neural influences.

This study developed a novel mouse model of catamenial epilepsy by manipulating neurosteroid levels and demonstrated that withdrawal increases seizure susceptibility, potentially linked to changes in GABAA receptor-subunit plasticity.

This study reports the development of the first rodent model for androgenetic alopecia, demonstrating that overexpression of androgen receptors in mice delays hair regeneration and can be used to test new treatments.

This study suggests that the HCR risk allele within the PSORS1 locus may contribute to psoriasis susceptibility by altering gene expression related to skin structure and differentiation, although these changes alone might not result in clinical symptoms.

This study found that ion-paired solutions significantly improved the skin penetration of risedronate in hairless mice compared to risedronate alone.

Proteomic analysis can identify genetic differences in mouse hair, helping understand hair defects and variations.

Multiple mouse desmoglein 1 isoforms have distinct roles in skin and hair development.

This study concluded that the frizzy mutation in mice is linked to a T to A transversion in Prss8 and is orthologous to the 'hairless' mutation in rats.