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This study found that aligned electrospinning membranes enhance skin wound healing by upregulating MMP12 expression and inhibiting fibroblast migration, which results in reduced scar formation, providing valuable insights for developing more effective biological dressings.

In this study, PDO, PLLA, and PCL thread implants in ageing rat skin did not alter MMP1 gene expression but maintained collagen levels similar to young skin without UV-B exposure, suggesting possible benefits for skin collagen but not gene expression modification.

The study identified increased IL-24 expression in keratinocytes and fibroblasts exposed to particulate matter, contributing to skin aging by promoting conditions similar to age-related changes such as increased MMP1 expression and decreased type I collagen production.

Combining certain treatments, including FOL005, may improve healing of difficult wounds.

This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.

This study found that selective androgen receptor modulators (SARMs) significantly inhibited tumor growth and metastasis-promoting factors in AR-positive triple-negative breast cancer models.

This study identified altered expression of MMP-19 in the skin's epidermal layers during diseases like psoriasis and eczema, implying a role in disease processes.

This study found that adipose‐derived stem cells can restore skin barrier function and inhibit photoaging-related responses in UVB-irradiated mice, suggesting a potential therapeutic role in managing skin photoaging.

This study found that photoexposure significantly increased the gene expression of altered elastin, MMP12, and LOX, as well as the protein expression of tropoelastin and fibrillin-1, in skin models.

In this study, women with the GG polymorphism of the MMP1 gene promoter were found to have a higher likelihood of being diagnosed with polycystic ovary syndrome.

This study found that the FGF-2 mimetic SUN11602 and VEGF mimetic ONO-1301 had unique effects on skin fibroblasts and keratinocytes, indicating potential for improving wound healing.

This study reported that atelocollagen enhances collagen synthesis and reduces oxidative stress in aged skin by increasing glycine uptake through GlyT1, resulting in improved skin elasticity and collagen density in aged mice, with effects superior to glycine alone.

This study found that a specific fragment of AIMP1 secreted by hair follicle stem cells can stimulate dermal papilla cells and promote hair regrowth.

This study found that electrospinning membranes with smaller fiber diameters significantly improved skin wound healing by promoting cell proliferation and encouraging reparative macrophage transformation.

In this study, researchers created a detailed human skin cell atlas by analyzing over 700,000 cells, finding that disrupted communication among specific immune and stromal cell subsets may play a key role in initiating and sustaining chronic skin inflammation in atopic dermatitis.

This study found that topically applied melatonin exerts significant anti-aging effects on human scalp skin ex vivo, including increased SIRT1 expression and reduced mTORC1 pathway activity.

This study identified distinct differences between mature and immature hypertrophic scars of the head and neck, with immature scars showing higher TGF-β expression and more pronounced inflammatory reactions.

This study found that ageing in women leads to significant structural and biological changes in the scalp hair follicle environment, which may affect hair growth.

This study developed a kidney-specific knockout mouse model lacking the Flcn gene, which recapitulates human Birt-Hogg-Dubé kidney tumorigenesis and shows that mTOR pathway inhibition with rapamycin can suppress tumor growth.

In this study, copper-doxorubicin liposomes with multidose therapy reduced systemic toxicity compared to ammonium sulfate-loaded doxorubicin liposomes, while combinatorial strategies further enhanced tumor regression and accumulation.

In this study, three patients with extensive alopecia areata showed varying degrees of hair regrowth after 20 weeks of treatment with ustekinumab, a cytokine-targeting therapy.

This study identified upregulation of genes linked to fibroproliferative disorders, such as platelet-derived growth factor and collagen genes, in patients with central centrifugal cicatricial alopecia, suggesting potential therapeutic targets.

This study observed that aging leads to significant structural and biological changes in the scalp's hair follicle environment in women, which may affect hair growth.

This study found that UVB irradiation alters skin stem cell niches leading to signs of photoaging, which may be reversed by adipose-derived stem cells through BMP4 pathway modulation and niche remodeling.

This study found that basal cell carcinoma cells differentiate along hair follicle lineages and may be influenced by hair follicle cycle modulators for potential therapeutic targeting.

This review highlights that exosomes from adipose-derived stem cells, particularly those enriched with circ-Ash1l, can inhibit ferroptosis and reduce UVB-induced skin aging by delivering GPX4-promoting signals to damaged cells, thus offering a potential regenerative therapy for photoaged skin.

This study demonstrated that SHFKO significantly accelerated healing in acute radiation-induced skin injuries, with mechanisms involving apoptosis inhibition, suppression of inflammation, and restoration of ROS balance, suggesting its potential as a novel multi-target therapy for radiodermatitis.

This study demonstrated that skin organoids derived from human stem cells can model cutaneous tuberculosis, revealing that fibrosis development in Mycobacterium tuberculosis-infected organoids is linked to the PI3K-AKT and AP1 pathways in fibroblasts, and suggesting the potential for antifibrotic treatment evaluation.

This study found that age-related changes in scalp dermal fibroblasts, including increased MMP-1 and reduced ECM components, may significantly affect the hair follicle environment and contribute to hair aging.

This study describes a new method for isolating intact human eccrine glands from scalp follicular units, potentially advancing research on sweat gland physiology.