Sanhuang Fukang Oil Alleviates X-Ray-Induced Skin Injury by Reducing Inflammation and Apoptosis: An In Vivo Study

    January 2026 in “ Frontiers in Pharmacology ”
    Ruochen Zhu, Mandi Lin, Wei Deng … Mei Huang
    Studysummary This study demonstrated that SHFKO significantly accelerated healing in acute radiation-induced skin injuries, with mechanisms involving apoptosis inhibition, suppression of inflammation, and restoration of ROS balance, suggesting its potential as a novel multi-target therapy for radiodermatitis.
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    Research cited in this study 5

    1. Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis International journal of molecular sciences · 2024
    2. PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds Cells · 2023
    3. Establishment and Characterization of a Radiation-Induced Dermatitis Rat Model Journal of Cellular and Molecular Medicine · 2019
    4. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    5. Mechanisms Regulating Skin Immunity and Inflammation Nature Reviews Immunology · 2014