Sanhuang Fukang Oil Alleviates X-Ray-Induced Skin Injury by Reducing Inflammation and Apoptosis: An In Vivo Study

January 2026 in “ Frontiers in Pharmacology ”

Ruochen Zhu, Mandi Lin, Wei Deng, Xintong Jian, Chiwei Chen, Xinlei Shi, Milin Lai, Mei Huang

Sanhuang Fukang oil radiodermatitis apoptosis pro-inflammatory mediators MAPK/PI3K-AKT pathway ROS homeostasis radiation dermatitis SHFKO

TLDR Sanhuang Fukang oil helps heal radiation skin injuries by reducing inflammation and cell death.

The study found that Sanhuang Fukang oil (SHFKO) effectively treats radiodermatitis by promoting faster healing of radiation-induced skin injuries. It works through multiple mechanisms, including inhibiting apoptosis, reducing pro-inflammatory mediators, inhibiting the MAPK/PI3K-AKT pathway, and restoring ROS homeostasis. These results indicate that SHFKO could be a promising candidate for clinical development in treating radiation dermatitis, providing a multi-target therapeutic approach that differs from conventional methods.

View this study on public-pages-files-2025.frontiersin.org →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis

1 citations , March 2024 in “International journal of molecular sciences”

Radiation therapy damages skin structure and immune function, causing inflammation and potential hair loss.

research PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

9 citations , June 2023 in “Cells”

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

research Establishment and Characterization of a Radiation-Induced Dermatitis Rat Model

16 citations , February 2019 in “Journal of Cellular and Molecular Medicine”

Researchers created a rat model to study skin damage caused by radiation, which could help develop new treatments.

research Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF

117 citations , March 2017 in “Nature Communications”

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

research Mechanisms Regulating Skin Immunity and Inflammation

610 citations , April 2014 in “Nature Reviews Immunology”

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.