The Effect of Zinc Sulfate in the Prevention of Radiation-Induced Dermatitis

    January 2004 in “ Journal of Radiation Research ”
    Mustafa Vecdi Ertekin, Salim Başol Tekin, Fazlı Erdoğan, İhsan Karslıoğlu, Akçahan Gepdíremen, Orhan Sezen, Ercan BALCi, Cemal Gündoğdu
    TLDR Zinc sulphate may help reduce skin damage from radiation therapy.
    The study investigated the protective effects of zinc sulphate against radiation-induced dermatitis in Sprague-Dawley rats. Rats were divided into four groups, with two groups receiving 30 Gy of gamma irradiation and either 5 mg/kg/day or 10 mg/kg/day of zinc. Results showed that zinc significantly reduced the severity of radiodermatitis compared to the group that received only radiation. The RT+10 Zn group exhibited the most protection, with reduced epidermal atrophy, dermal degeneration, and hair follicle atrophy. These findings suggested that zinc sulphate could potentially reduce radiation-induced toxicity in cancer patients undergoing radiation therapy.
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