Zinc Deficiency Dermatoses: Etiology, Clinical Aspects, and Treatment

August 1982 in “ PubMed ”

K Weismann, H Høyer

zinc deficiency alopecia dermatitis parakeratotic psoriasiform dermatitis zinc therapy acrodermatitis enteropathica

TLDR Zinc deficiency causes skin issues and hair loss, treatable with zinc supplements.

The document discussed zinc deficiency dermatoses, highlighting that low serum zinc concentration and declining alkaline phosphatase activity were indicative of the condition. Clinically, it presented as dermatitis on hands, feet, face, and anogenital region, with acute cases showing vesico-bullous eruptions and chronic cases displaying parakeratotic psoriasiform features. Additional symptoms included widespread eczema craquelée, alopecia, Beau lines on nails, and hair changes. Treatment involved zinc therapy, typically zinc sulfate, administered intravenously or orally in high doses, though long-term high doses could affect copper metabolism and were mainly recommended for acrodermatitis enteropathica.

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