Mature And Immature Hypertrophic Scars Of The Head And Neck: Clinical-Morphological, Pathogenetic Characteristics
May 2022
in “
Голова и шея.
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TLDR Immature hypertrophic scars on the head and neck have more inflammation and TGF-β, affecting treatment choices.
The study aimed to investigate the clinical, morphological, and pathogenetic features of mature and immature hypertrophic scars (HS) on the head and neck, involving 176 patients with scar tissue biopsies. It identified differences in collagen accumulation, myofibroblastic elements, α-SMA, TGF-β, and MMP1 macrophages between mature and immature HS. Immature HS showed higher TGF-β expression, a pronounced inflammatory reaction, and active neoangiogenesis. The study highlighted the role of TGF-β in HS formation and provided insights for selecting appropriate treatments for patients with these scars.
