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This article describes the synthesis of novel polyamine-modified minoxidil analogs and conjugates to potentially enhance minoxidil's biological activity, selectivity, and water solubility, but reports no new biological results.

This study reported that certain minoxidil conjugates, specifically those with spermine, methylenedianiline, and diaminofluorene, were able to induce differentiation in HL-60 acute myeloid leukemia cells without toxicity at a concentration of 10 μM.

This study found that polyamines enhance genome integrity by facilitating homologous recombination-mediated DNA repair, suggesting a novel role for polyamines beyond promoting cell growth and proliferation.

This study found that isotretinoin, a drug commonly used for acne, inhibits polyamine transport in Trypanosoma cruzi, leading to trypanocidal effects, and suggests its potential as a treatment for Chagas disease without affecting mammalian cell viability.

In this study, topical application of α-methylspermidine during the telogen phase in mice induced hair growth by increasing the polyamine pool and mimicking the anagen phase's characteristics.

This chapter reviews the role of nanoparticles in wound healing, exploring current therapies, developments, and future directions, but reports no new clinical results.

Hyaluronic acid microneedles help deliver minoxidil derivatives effectively for hair regrowth.

This study found that elevated epidermal ODC activity in transgenic mice promotes skin tumor development by recruiting bulge stem cells, rather than through reactive oxygen species generation by polyamine catabolic oxidases.

This study found that in estrogen receptor-positive breast cancer cells, 17β-estradiol repressed polyamine oxidase transcription by interacting with AP-1 sites on its promoter.

This study found that a ceria nanozyme-integrated microneedles patch accelerated hair regeneration in an androgenetic alopecia mouse model more effectively than minoxidil, with reduced application frequency and minimal skin damage.

This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.

This article discusses potential roles for retinoids in hair regrowth and proposes future studies, reporting no new experimental results.

This report discusses the Ninth World Congress for Hair Research and highlights the potential of hair follicle studies to advance understanding of various diseases, with no new clinical results presented.

This study found that the combination of MT-DADMe-ImmA and MTA selectively induced apoptosis in head and neck squamous cell carcinoma cell lines FaDu and Cal27, but not in normal fibroblasts or MTAP-deficient breast cancer cells.

This study provides the first direct evidence that spermidine can stimulate hair growth and modulate human epithelial stem cell biology in cultured human hair follicles.

This study suggests that polyamines regulate CK2 enzyme activity and its subcellular distribution, as demonstrated in mouse models and cell cultures with elevated levels of ornithine decarboxylase.

This research suggests that defects in keratinocyte differentiation due to putrescine accumulation in SSAT transgenic mice lead to skin changes and hair loss, and reducing putrescine can promote hair regrowth.

In this study, the researchers discovered that specific polyamine depletion enhances stemness in hair follicle stem cells through a mechanism independent of mRNA translation.

This review explores the use of topical and transdermal delivery for drugs and cosmetics, highlighting the benefits of avoiding side effects and rapid metabolism, with a focus on nanoparticulate formulations and techniques for studying skin penetration.

This study presents a method for directly measuring the solubility of solid chemicals in the skin's stratum corneum under various humidity conditions, emphasizing its importance for dermal drug delivery and chemical safety assessments.

This systematic review examines the landscape of cosmetic microneedling using SWOT analysis, identifying strengths like precise delivery and self-administration, while noting challenges such as potential skin damage and regulatory issues, with opportunities in AI-enhanced targeted treatments noted by these researchers.

This study explored a keratin, sodium alginate, and carboxymethyl chitosan hydrogel modified with tannic acid and found it to have promising wound-healing qualities, including similar elasticity to human skin, antimicrobial and antioxidant properties, and effective water retention. These attributes suggest potential applications in biomedical engineering.

This review discusses the mechanisms of skin aging, highlighting the roles of stem/progenitor cells, genetic and environmental factors, and suggests potential for cell-based therapies, but reports no new experimental findings.

This study reviewed 16 notable drug repurposing patent applications from 2025, highlighting potential new uses such as guanfacine for autonomic dysfunction and disulfiram for subarachnoid hemorrhage survival, though many disclosures lack peer-reviewed studies and no patents are granted.

This review discusses the design and advances of lipid–polymer hybrid nanoparticles as promising delivery systems for genome editing strategies, highlighting their potential in biomedical applications.

This review explores nano-quercetin formulations to enhance the solubility, stability, and targeted delivery of quercetin, highlighting its potential efficacy in treating cancer, inflammation, metabolic diseases, and tissue regeneration, though challenges in biocompatibility, toxicity, and production remain, per this source.

This study reports that the metanephrine content was significantly higher in patients with alopecia areata compared to those without the condition.

This study found that 'smart' peptide hydrogels improved wound healing in a rat model of partial thickness burns, achieving greater wound closure and faster debridement compared to a standard treatment.

This chapter reviews the use of electrospun matrices in creating tissue-engineered skin substitutes and reports no new clinical results; it emphasizes the need for a cell-friendly microenvironment.