January 2014 in “Journal of Physiology & Pathology in Korean Medicine” Microneedle roller therapy can help hair grow.
In this study, researchers found that adding zygomaticotemporal nerve blocks to supratrochlear and supraorbital nerve blocks in mesotherapy lowered pain significantly during and after the procedure for hair regrowth in alopecia patients.
9 citations
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January 2018 in “Medical research archives” This review discusses the therapeutic use of photobiomodulation for various skin conditions, highlighting its efficacy in accelerating tissue repair, reducing inflammation, and treating pigmentary disorders and other skin diseases, but it reports no new clinical results.
In this study, microneedling radiofrequency followed by topical exosome application was associated with significant increases in hair density and diameter, showing promising potential as a therapy for pattern hair loss.
October 2025 in “Journal of Cosmetic Dermatology” This study found that the AOPT-MTL mode is an effective and safe treatment option for nasal blackheads in Asians, indicating potential for widespread clinical use.
September 2022 in “The Egyptian Journal of Hospital Medicine” This review article discusses microneedling as a non-surgical treatment option in dermatology, highlighting its benefits for scar improvement through collagen induction and reporting its popularity among practitioners due to its cost-effectiveness and simplicity.
57 citations
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December 2011 in “Lasers in Surgery and Medicine” This study suggests that selective photothermolysis of sebaceous glands using free electron laser pulses may offer a novel approach to treating acne by causing targeted thermal damage without affecting the epidermis.
January 2024 in “Theranostics” This study found that hypoxia-preconditioned HF-MSC-derived exosomes improved therapeutic outcomes in models of ulcerative colitis, potentially through miR-214-3p-mediated pathways affecting mitochondrial function and inflammatory responses.
11 citations
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July 1999 in “Plastic and Reconstructive Surgery” This study reported successful outcomes in over 40 patients undergoing reparative surgical techniques for previously unsuccessful hair restoration, with significant improvements in appearance despite potential challenges like limited donor hair and scalp scarring.
November 2025 in “Bioactive Materials” In this study, researchers developed a DNA/GelMA-based cryogel platform that uses phototherapy to combat MRSA infection and promote scarless wound healing, showing enhanced bactericidal activity, tissue regeneration, and anti-inflammatory effects in vivo, suggesting a promising approach for treating infected skin wounds.
1 citations
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July 2025 in “Advanced Science” This study developed multifunctional microneedle patches with CTB nanozymes that successfully eradicated MRSA infections in wounds by combining near-infrared laser-induced nitric oxide release and local hyperthermia, while also regulating oxidative stress, inflammation, and angiogenesis through specific signaling pathways.
June 2024 in “Lasers in Surgery and Medicine” This study found that the novel dermal cooling system was an effective and safe treatment for reducing pigmentation in benign pigmented lesions in Asian patients, with minimal side effects.
March 2026 in “Journal of Nanobiotechnology” This study developed a hydrogel microneedle system combining ginseng-derived exosomes and biomimetic nanoparticles to address oxidative stress, inflammation, and melanocyte deficiency in vitiligo, showing significant repigmentation in mice within 3 weeks by enhancing melanocyte protection and keratinocyte proliferation.
June 2024 in “Cermin Dunia Kedokteran” This review discusses the benefits and applications of low level laser therapy in cosmetic dermatology, particularly for skin conditions and pigmentation disorders, but reports no new clinical results.
In this study, women in their 40s with hair loss showed significant improvements in hair properties such as pore density and hair thickness when treated with a caffeine-based scalp ampoule and Microneedle Therapy System, compared to a caffeine-free control.
August 2025 in “The American Journal of Medical Sciences and Pharmaceutical Research” This study suggests that noninvasive carboxytherapy methods, like gel formulations and device-assisted delivery, can significantly improve skin conditions with high safety and no recovery time, particularly in sensitive areas.
May 2025 in “RCMOS - Revista Científica Multidisciplinar O Saber” This study, through a review of existing literature, observed that massage techniques may serve as a beneficial complementary therapy for male androgenetic alopecia by enhancing blood circulation and overall follicle nutrition, with combined approaches possibly increasing treatment efficacy despite a lack of standardized protocols.
16 citations
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January 2023 in “Journal of Cosmetic Dermatology” This study found that micro-needling combined with topical 5-fluorouracil (5-FU) was more effective in treating vitiligo patches than topical tacrolimus, with significant improvement observed in six patients, although it caused mild side effects like erythema and irritation.
This bibliographic review highlights the importance of microneedling as a dermatological technique for treating androgenetic alopecia, emphasizing its potential benefits and the need for personalized treatment by skilled dermatologists.
April 2024 in “International journal of molecular sciences” This narrative review discusses the promising role of photobiomodulation in dermatology, emphasizing its non-invasive nature and potential benefits, but acknowledges the need for further research to establish standard protocols.
October 2025 in “Skin Research and Technology”
92 citations
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January 1999 in “Physics in Medicine and Biology” This study developed and validated a computational model to optimize skin precooling methods for minimizing thermal damage during laser procedures.
2 citations
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May 2023 in “Photobiomodulation, photomedicine, and laser surgery” This editorial reviews how photobiomodulation therapy might effectively treat both hyperpigmentation and depigmentation skin disorders, but reports no new clinical results.
June 2026 in “ACS Applied Nano Materials” This study developed and tested a novel microneedle treatment loaded with nanoparticles for vitiligo, leading to enhanced skin repigmentation by targeting immune cells and reducing oxidative stress in a minimally invasive manner.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This narrative review suggests that while mechanical scalp stimulation has a plausible mechanism for aiding androgenetic alopecia, its clinical evidence is insufficient, and the marketing of stimulation devices currently outpaces their efficacy data.
13 citations
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February 2020 in “Journal of the American Academy of Dermatology” This study found that both oral tranexamic acid and microneedling improve melasma treatment outcomes when added to standard therapy, with microneedling showing a more sustained remission.
8 citations
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March 2022 in “Journal of Cosmetic Dermatology” This study concluded that mesotherapy appears effective for treating pattern hair loss, but emphasizes a need for more research comparing it to other treatments due to limited sample sizes.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This document, authored by Jack Schaffer, establishes prior art for methods aimed at treating disorders related to tissue function by restoring bioelectric communication among cells, preceding specific applications for conditions like androgenic alopecia and age-related sexual dysfunction.
January 2001 in “대한피부과학회지” This study reports that oral minipulse therapy with betamethasone was effective in promoting hair regrowth and managing alopecia areata with fewer side effects than traditional pulse therapies.
January 2026 in “Updates in clinical dermatology”