5 citations
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March 2016 in “Experimental and molecular pathology” In mouse models of alopecia areata, this study found increased dilation of lymphatic vessels in affected mice, with associated changes in gene expression related to vascular growth and immune cell movement.
August 2025 in “Frontiers in Microbiology” This study found that microneedling treatment improved hair regeneration in an animal model of alopecia areata and positively influenced the gut microbiome by restoring microbial diversity and altering short-chain fatty acid levels.
179 citations
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June 2000 in “The American journal of pathology” This study reports that the asebia-2J mutation in mice affects sebaceous gland function and leads to hair follicle destruction, offering a model for human scarring alopecias.
127 citations
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December 2005 in “Experimental Dermatology” This study provides evidence that psychoemotional stress inhibits hair growth in mice by affecting the brain-hair follicle axis, with specific neuropeptides and treatments modulating this effect.
99 citations
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February 2000 in “PubMed” This study found that overexpression of PKCepsilon in transgenic mice reduced papilloma development but accelerated carcinoma formation in a skin tumor promotion model.
37 citations
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June 2000 in “Experimental dermatology” This study investigated a spontaneous mutation in mice resulting in hair abnormalities and elevated IgE levels, which resembles human Netherton's syndrome and monilethrix.
31 citations
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December 2021 in “Materials” In a study using a mouse model of diabetes, chitosan-based hydrogels increased healing markers and improved wound closure and tissue repair compared to untreated wounds, but human efficacy needs further validation.
30 citations
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September 2003 in “Experimental Dermatology” In this study on a murine model, researchers observed that a 5% minoxidil solution reduced stress-induced changes in hair growth, suggesting its potential for managing stress-related hair loss in humans.
25 citations
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October 1984 in “Journal of Clinical Investigation” This study demonstrated that human sebaceous glands can be successfully transplanted onto nude mice, where androgen stimulation increases gland volume, cell size, and labeling index.
17 citations
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June 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that mice with a Cx43 mutation exhibited slower and asynchronous hair regrowth with severe cuticle weathering, mimicking aspects of hair phenotype in some ODDD patients.
17 citations
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November 2001 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that Stat3 removal in keratinocytes of mice impairs healing and disrupts the normal hair cycle, leading to skin ulcers and hair loss as they age.
14 citations
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July 2007 in “Lupus” In this study, repeated pregnancies in a murine model of systemic lupus erythematosus altered skin inflammation and cytokine expression but worsened kidney function and survival compared to controls.
2 citations
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December 2007 in “Microbial pathogenesis” This study found that in mice, Bacillus anthracis infections destroy hair follicles by progressing inward from the surface and clear when inflammatory cells disperse the bacteria after 3-4 days.
December 2025 in “Nature Communications” In this study using mouse models, researchers found that elevated IL-17a in aged olfactory epithelium impairs olfactory function, while IL-17a inhibition promotes regeneration and mitigates age-related decline.
October 2024 in “Journal of the Endocrine Society” This study observed that gender-affirming hormone therapy differentially affects metabolism in mice, with the specific metabolic impacts dependent on the type of hormonal treatment used.
December 2023 in “Frontiers in pharmacology” In this study, intrathecal progesterone administration initially worsened mechanical allodynia in mice after nerve injury, but later reduced pain when applied during the maintenance phase, highlighting distinct roles for cytochrome P450c17 and 5α-reductase in neuropathic pain modulation.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that combining UVB irradiation with anti-CD154 antibody improves the survival of hair follicle allografts in a humanized mouse model, suggesting a synergistic effect for allogeneic hair transplantation.
North American ginseng extract helped regrow hair in balding mice.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In a study using testosterone-induced alopecia models in Wistar mice, researchers reported that a 10% Euphorbia hirta herbal oil formulation showed potential as a natural alternative for promoting hair growth, suggesting efficacy comparable to synthetic drugs over a 30-day period.
December 2022 in “Acta Ophthalmologica” In this study, dutasteride treatment in retinitis pigmentosa mice increased photoreceptor survival and reduced glial activation, suggesting it may offer a neuroprotective effect.
75 citations
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March 1998 in “Journal of Investigative Dermatology” This study reports that transgenic mice carrying Clone B DNA developed spontaneous melanomas likely due to an interruption in genes regulating cell growth in melanin-producing cells, offering a model for melanoma research.
12 citations
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December 2011 in “Canadian Journal of Microbiology” In this study, all five serotypes of Ureaplasma were found to be pathogenic in a mouse model of lower genital tract infection, with serotype 4 showing the greatest pathogenicity.
7 citations
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February 2025 in “Stem Cell Research & Therapy” In a study using a mouse model, HF-MSCs were reported to enhance ovarian function in cyclophosphamide-induced premature ovarian failure more effectively than HU-MSCs, potentially by preventing ferroptosis in granulosa cells via the KEAP1/NRF2/HO-1 pathway.
2 citations
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January 2023 in “Pharmaceuticals” This study found that in male mice, microglial changes due to a Parkinson's-like lesion were influenced by sex hormones, with dutasteride treatment preventing some effects.
April 2024 in “Histochemistry and cell biology” In this study, NAC was observed to counteract the negative effects of cyclophosphamide on hair follicles in mice, preserving both biochemical parameters and hair structure, suggesting its potential as a therapeutic option for chemotherapy-induced hair loss.
April 2023 in “Pharmacognosy Magazine” In a study using a mouse model, Cerasus serrulata flower extracts significantly increased β-catenin and VEGF expression, promoting hair blackening and suggesting potential as a treatment for premature greying.
135 citations
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May 1994 in “Medical Entomology and Zoology” This collection reviews various animal models for dermatological research, particularly focusing on genetic mutations in laboratory mice, and reports no original findings.
August 2025 in “Frontiers in Pharmacology” In this study, PA-011, a traditional Chinese medicine extract, was shown to improve hair growth in alopecia areata model mice by reducing skin inflammation and altering skin microbiota, indicating its potential therapeutic role for this condition.
178 citations
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June 1994 in “Journal of Investigative Dermatology” This study found that a non-scarring alopecia in C3H/HeJ mice resembles human alopecia areata and may serve as a valuable model for studying specific subtypes of the human condition.
143 citations
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May 2002 in “PubMed” This study found that the retinoid LGD1069 suppressed mammary tumorigenesis in a mouse model without observable toxicity, while TTNPB showed modest effects but was associated with significant toxicity.