Progressive and Destructive Hair Follicle Infections in a Murine Cutaneous Anthrax Model
December 2007
in “
Microbial pathogenesis
”
TLDR Anthrax bacteria can infect and destroy hair follicles in mice, but the immune system eventually clears the infection.
The study investigated the susceptibility of hair follicles to Bacillus anthracis in a murine model, focusing on whether actively growing (anagen) or resting (telogen) follicles were more prone to infection. The results showed that B. anthracis could invade both anagen and telogen hair follicles equally, unlike dermatophytes which only infect anagen follicles. The infection typically started at the superficial parts of the follicles and progressed deeper. This research provided insights into the pathogenesis of cutaneous anthrax, highlighting the role of hair follicles as a site of bacterial proliferation.
