Dermal Lymphatic Dilation in a Mouse Model of Alopecia Areata

    March 2016 in “ Experimental and molecular pathology ”
    John P. Sundberg, C. Herbert Pratt, Kathleen A. Silva, Victoria E. Kennedy, Timothy M. Stearns, Beth A. Sundberg, Lloyd E. King, Harm HogenEsch
    TLDR Mice with alopecia areata had wider lymphatic vessels in their skin.
    The study investigated dermal lymphatic dilation in a mouse model of alopecia areata (AA) and found significant dilation of dermal lymphatic vessels in affected mice. While the number and distribution of lymphatics did not change, dilation was confirmed using LYVE1 immunohistochemistry. Transcriptome analysis showed no significant changes in Lyve1 transcripts, indicating dilation rather than proliferation. Several genes related to vascular growth and immune cell movement were upregulated, particularly at 10 weeks post-grafting when clinical signs of AA appeared. The study highlighted the role of lymphatic changes in AA and suggested potential therapeutic targets.
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