January 2025 in “Journal of Materials Chemistry B” This research highlights the potential of using nanomaterials with advanced reactive oxygen properties to target oxidative stress in hair follicle tissue, which is associated with androgenetic alopecia, addressing a gap in the current understanding of AGA treatments.
13 citations
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November 2014 in “Pediatric emergency care” This study reports that the ingestion of a small amount of topical minoxidil by a child resulted in significant intoxication, suggesting the need for enhanced child-resistant packaging.
December 2009 in “Digital Library of Theses and Dissertations (Universidade de São Paulo)” This study found that iontophoresis significantly increased the retention of minoxidil sulfate in hair follicles, potentially improving drug delivery for androgenic alopecia treatment.
10 citations
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December 1991 in “Annals of the New York Academy of Sciences” This study found that minoxidil increases the expression of a reporter gene linked to hair growth in cultured hair follicles from transgenic mice, suggesting a potential model for studying hair biology.
19 citations
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October 2017 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that the MXD/HP-β-CD GEL formulation promoted greater hair growth and improved gene expression related to hair growth in male rats compared to MXD solution or control groups.
23 citations
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November 1964 in “Journal of Dairy Science” This study found that high molybdenum levels in the diet, especially with added sulfate sulfur, led to symptoms like alopecia and hair color loss in heifers; however, these were corrected by adding copper.
January 2025 in “Reactions Weekly” November 2024 in “Reactions Weekly” May 2023 in “Reactions Weekly”
2 citations
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July 2022 in “Journal of the American Academy of Dermatology” In this study, researchers aimed to evaluate the safety and tolerability of low-dose oral minoxidil in adolescents, as existing data on its use in this population are limited and there are no specific pediatric guidelines for prescribing it. Results are not reported.
5 citations
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December 1991 in “Annals of the New York Academy of Sciences” Minoxidil boosts hair growth by undergoing a process in hair follicles and certain skin cells, and by increasing the production of compounds essential for hair growth and maintenance.
May 2021 in “Open Access Macedonian Journal of Medical Sciences” This study found that individuals with premature hair graying had significantly lower levels of antioxidants compared to controls, but the severity of graying did not significantly correlate with oxidative stress levels.
1 citations
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October 1990 in “The Lancet” Using minoxidil for hair growth may cause skin lesions in some people, and taking breaks from nitrate patches for angina might worsen symptoms.
2 citations
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August 2019 in “PubMed” This abstract reports that topical minoxidil is currently the only FDA-approved treatment for pattern hair loss in both men and women.
6 citations
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May 2022 in “Journal of Organometallic Chemistry” This study developed a catalytic system using indenyl-molybdenum(II)-bipyridine complexes and ionic liquid solvents to achieve a 95% yield of campholenic aldehyde from α-pinene oxide under mild conditions.
119 citations
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June 2005 in “Journal of Molecular and Cellular Cardiology” This article reviews the therapeutic potential of potassium channel openers for various conditions related to metabolic distress but does not report new clinical results; it emphasizes the need for further research.
November 2024 in “Cureus” In this case report, a 24-year-old male experienced severe vasoplegic shock after ingesting a large amount of minoxidil solution, requiring an unprecedented 180 hours of norepinephrine support for blood pressure maintenance, highlighting the need for extensive supportive care following minoxidil intoxication.
4 citations
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December 2008 in “The Thai Journal of Veterinary Medicine” This study found that zinc methionylglycinate supplementation improved haircoat characteristics and zinc absorption in dogs compared to zinc sulfate.
11 citations
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April 2009 in “Pharmacotherapy” Minoxidil can cause deadly skin reaction; monitor patients closely.
May 2024 in “Journal of biomaterials science. Polymer ed.” This study found that three-layer dissolving microneedles for delivering Minoxidil showed improved skin drug penetration and reduced irritation risk compared to traditional Minoxidil cream, suggesting a promising alternative for alopecia areata treatment.
1 citations
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July 2025 in “Advanced Materials” This study reports on a zinc-coordinated tri-enzyme nanogel system (Zn@nGSC) that mimics natural enzymatic processes to enhance enzymatic activity and cascade efficiency, showing potential in wound healing, hyperglycemia treatment, and antibacterial effects in a murine model of post-pancreatectomy.
December 2023 in “International Journal of Biological Macromolecules” This study found that MCS nanoparticles improved Minoxidil's hair growth effects in an animal model compared to the commercial formulation, but they were less effective than CS nanoparticles despite showing better solubility with minimal side effects.
1 citations
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October 2022 in “JAAD case reports” This report highlights a serious complication associated with low-dose oral minoxidil in treating female androgenetic alopecia, an adverse effect previously thought to be rare and minor.
June 2024 in “European Journal of Pharmaceutics and Biopharmaceutics” This study reported that using photoacoustic waves to enhance transdermal delivery of encapsulated minoxidil can significantly increase hair growth while reducing treatment frequency and systemic side effects.
1 citations
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July 2017 in “Microscopy and Microanalysis” In this study using C57BL/6 mice, researchers found that iron oxide nanoparticles permeated skin primarily through hair follicles and sebocytes, with absorption increasing over time.
February 2026 in “Scientific Reports” This preclinical study found that Mesenchymal Stem Cell-derived Conditioned Media formulations were safe and effective in rat and mouse models for treating chemotherapy- and radiation-induced oral mucositis, demonstrating improved tissue regeneration and healing, most notably at higher concentrations.
4 citations
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May 2020 in “Medicine in Drug Discovery” This study found that arylsulfatase enzymes in hair follicles can convert the active form of minoxidil back to its inactive form, potentially affecting its effectiveness in treating androgenetic alopecia.
November 2023 in “Current Dermatology Reports” This review found that oral minoxidil, particularly in low doses, is effective and safe for treating various types of hair loss, including androgenic alopecia, and may offer advantages over other treatments, such as improved convenience and enhancement of male sexual function.
October 2024 in “International Journal of Pharmaceutical Sciences Review and Research” This study reviewed existing literature on Androgenetic Alopecia treatments, finding that minoxidil promotes hair growth but can cause side effects due to its traditional formulations. Novel delivery systems like film-forming sprays may reduce these side effects and enhance efficacy.