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Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

Metformin helps improve symptoms and reproductive outcomes in people with polycystic ovary syndrome.

Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.

Vitamin E helps reduce PCOS symptoms and improves hormonal balance.

Skin problems like excessive hair growth, acne, and dark skin patches can be signs of Polycystic Ovarian Disease, which may also be linked to family history and a risk for diabetes.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Metformin improves hair growth and menstrual frequency in women with PCOS and hirsutism.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

The conclusion is that oral contraceptives and antiandrogens can treat hirsutism and acne in women with cutaneous hyperandrogenism, but more research is needed for effective treatments, especially for hair loss.

Quercetin may help with PCOS symptoms, but more research is needed.

Male hormones, or androgens, affect women's health in areas like mood and bone density, and hormone replacement therapy using antiandrogenic progestogens can improve mood disorders and alertness in menopausal women.

Insulin resistance is found in 20% of Thai women with PCOS, with age, waist size, skin changes, and abnormal blood fats increasing the risk.

Excessive body hair in women can be caused by various conditions and treated with medication like Diane® 35 or androgen blockers.

STK11 gene variations do not predict how well metformin will work for PCOS, but may affect hair loss and excess hair growth.

PCOS increases the risk of heart disease and type 2 diabetes in women.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.

Working night shifts for four days can lower the body's ability to use insulin, which may increase the risk of type 2 diabetes.

Testosterone and dihydrotestosterone affect hair growth, and new techniques like the folliculogram help study it, but fully understanding hair growth is still complex.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

Insulin-sensitizing drugs like metformin can help with ovulation, weight loss, and lower testosterone in some women with PCOS.

Hair growth is influenced by factors like genetics and nutrition, and more research is needed to understand hair loss and growth mechanisms.

Effective hirsutism management requires identifying the cause, combining new and traditional treatments, and setting realistic expectations for patients.

Obese women had more testosterone and less acne, but similar hair growth compared to non-obese women.

Early diagnosis and treatment of PCOS in young people is important to prevent long-term health problems.