TLDR Bariatric surgery improves ovulation rates in women with PCOS and obesity better than medical therapy.
The BAMBINI trial, a multicentre, open-label, randomised controlled trial, evaluated the impact of bariatric surgery versus medical care on ovulation rates in 80 women with polycystic ovary syndrome (PCOS), obesity, and menstrual irregularities. Participants were assigned to either vertical sleeve gastrectomy or medical therapy. Over 52 weeks, the surgical group had a median of 6 ovulations compared to 2 in the medical group, with 2.5 times more spontaneous ovulations (p<0.0007). The surgical group also showed significant improvements in weight, metabolic health, and psychological well-being, although symptoms like hirsutism, acne, and androgenic alopecia did not consistently improve. The study concluded that bariatric surgery is more effective than medical care for inducing spontaneous ovulation and improving metabolic health, supporting its inclusion as a treatment option for women with PCOS and obesity.
8 citations,
August 2023 in “The Journal of Clinical Endocrinology and Metabolism” Follow the latest international guidelines to assess and manage Polycystic Ovary Syndrome effectively.
189 citations,
March 2018 in “Human Reproduction Update” Women with PCOS are more likely to have impaired glucose tolerance and type 2 diabetes, especially if they are Asian or obese.
1540 citations,
October 2008 in “Fertility and Sterility” The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.
38 citations,
June 2004 in “Human Reproduction” The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.
3 citations,
February 2018 in “InTech eBooks” Traditional Chinese Medicine and acupuncture may improve Polycystic Ovarian Syndrome symptoms and reduce costs, but more research is needed.
November 2017 in “Elsevier eBooks” PCOS is a genetic disorder affecting women's reproductive health, with treatments focused on symptoms like insulin resistance and fertility.
467 citations,
October 2014 in “European Journal of Endocrinology” The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.
There are many ways to treat Polycystic Ovary Syndrome, including lifestyle changes, surgery, and various medications, but more research is needed for better treatments.
13 citations,
October 2011 in “Clinical Obstetrics and Gynecology” Women with PCOS-related infertility can often conceive with treatments like clomiphene and metformin, but managing pregnancy complications is important.
