Bariatric Surgery for Spontaneous Ovulation in Women with Polycystic Ovary Syndrome: The BAMBINI Multicentre, Open-Label, Randomised Controlled Trial

    June 2024 in “ The Lancet ”
    Suhaniya Samarasinghe, Bianca Leca, Shahd Alabdulkader, Georgios K. Dimitriadis, Allan Davasgaium, Puja Thadani, Kate Parry, Migena Luli, Karen O’Donnell, Brett Johnson, Ali Abbara, Florian Seyfried, Florian Seyfried, Ahmed Ahmed, Sherif Hakky, C. Tsironis, Sanjay Purkayastha, Carel W. le Roux, Stephen Franks, Vinod Menon, Harpal Randeva, Alexander D. Miras
    TLDR Bariatric surgery improves ovulation rates in women with PCOS and obesity better than medical therapy.
    The BAMBINI multicentre, open-label, randomised controlled trial aimed to compare the safety and efficacy of bariatric surgery versus medical care on ovulation rates in women with PCOS, obesity, and oligomenorrhoea or amenorrhoea. The study found that bariatric surgery significantly improved ovulation rates compared to medical therapy and behavioural modifications. This suggests that bariatric surgery could be a more effective treatment option for improving fertility prospects in women with PCOS and obesity.
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