Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that α-MSH may suppress IFN-γ-driven upregulation of ICAM-1 in human dermal fibroblasts, suggesting potential roles for melanocortins in inflammatory skin disorders beyond collagen synthesis effects.

In this study, I-PRF, a blood-derived biomaterial without anticoagulants, was found to inhibit melanin production and reduce oxidative stress damage in a rat model of melasma, suggesting it as a safe and cost-effective treatment option.

In this study, Diane was reported to effectively treat acne, seborrhoea, androgenic alopecia, and mild hirsutism in hirsute women, with its effectiveness influenced by the severity and duration of the condition.

This review suggests that melasma may be a photoaging skin disorder affecting genetically predisposed individuals, which could significantly influence its treatment and prevention strategies.

This study found that applying topical thymidine dinucleotide (pTT) to newborn mice before UV exposure delayed and reduced melanoma development compared to untreated controls.

This review highlights the promising clinical outcomes of sacituzumab tirumotecan (sac-TMT), an antibody-drug conjugate for breast cancer that targets TROP2, demonstrating improved response rates and progression-free survival, with manageable safety concerns including primarily mild-to-moderate nausea and alopecia.

This study developed dissolving microneedles using specific polymers for transdermal delivery of rizatriptan benzoate, demonstrating improved drug skin penetration and significant alleviation of migraine symptoms in vivo compared to passive diffusion, suggesting potential advantages over conventional treatment methods for acute migraine.

This report details two cases of Lichen spinulosus in the submental area, treated effectively and safely with topical tacalcitol cream.

Alpha-MSH affects mitochondrial function, and MC1R mutations may increase skin aging.

In this study of hydroponically grown tomatoes, the authors reported that adding melatonin at 10-30 μmol·L-1 effectively enhanced lateral root development, root hair growth, biomass accumulation, and root activity by influencing related gene expression and hormone levels.

This study found that the LightSheer Diode EP Laser System significantly reduced hair growth among women with hirsutism, with side effects disappearing within three days and no long-term skin pigmentation issues observed.

The new method can measure sleep-related hormones in hair effectively and could help track long-term sleep patterns.

This study found that compounds isolated from the Etlingera alba rhizome exhibited cytotoxic and anti-metastatic activity, with potential for development against Triple-Negative Breast Cancer.

This review discusses the pharmacological profile of teriflunomide for treating relapsing multiple sclerosis, highlighting its safety and effectiveness in reducing relapses and slowing disability progression, though direct comparisons with other oral medications are lacking.

INTASYL is a promising, adaptable RNAi technology for treating skin cancers.

In this study, researchers found that Compound Baqian Danshen Liniment may improve vitiligo in mice by promoting melanocyte activity and reducing inflammation and oxidative stress.

This review discusses the potential role of melatonin in treating androgenetic alopecia and does not report new clinical results; it highlights the need for further trials.

In this study, exposure to Myrtus communis leaf extract significantly reduced IL-1α expression and increased VEGF expression in human keratinocytes, which may relate to its traditional use for hair loss and wound healing; further research is necessary to understand its mechanisms.

In this study, researchers tested hair tonic formulations with varying concentrations of bitter melon extract and found that higher concentrations enhanced hair growth in rabbits, with the 15% extract showing the greatest effect without causing skin irritation.

This study found that theabrownin-selenium nanoparticles (TB-Se NPs) effectively target Malassezia-induced dermatitis through a dual antifungal and immunomodulatory mechanism, suppressing fungal overgrowth, reducing inflammation, and enhancing immune memory to prevent recurrence in a dermatitis model.

This study suggests that αMSH may play a regulatory role in human dermal papilla cells, potentially influencing immune and inflammatory responses in hair follicles, which could contribute to inflammatory alopecia.

This study found that maternal melatonin supplementation improved fur quality in Rex rabbit offspring by increasing hair follicle density and altering melatonin receptor gene expression in several organs.

This study found that patients with the MITF p.E318K variant are more likely to develop multiple primary melanomas and dysplastic nevi with uncommon dermoscopic patterns compared to non-carriers.

This study found that actively targeted AN2728-loaded nanocarriers reduced inflammation and improved skin condition in a mouse model of psoriasiform inflammation compared to free drug and non-targeted nanoparticles.

This study found that NIMP-R14-conjugated nanoparticles, loaded with roflumilast, effectively targeted neutrophils to reduce inflammation and improve symptoms in a mouse model of psoriasiform dermatitis, suggesting potential for targeted therapy in autoimmune skin diseases.

This study identified pantolactam based compounds as effective topical antagonists of the androgen receptor, reducing sebum components in a hamster model.

Treatments for melanin disorders exist, but more effective options needed.

This protocol outlines a study to evaluate whether photobiomodulation, alone or with melatonin, promotes hair regrowth in dogs with Alopecia X, reporting no new results yet.

In this study, a metformin-loaded rosemary-based nanoemulgel was found to significantly enhance hair follicle growth in rats, suggesting its potential as a new treatment for androgenetic alopecia due to its promising physicochemical properties and controlled drug release.

This case report suggests that melanin, as an energy generator, may offer a new perspective on studying and treating autoimmune disorders such as alopecia areata.