Anti-Vitiligo Mechanisms of Traditional Chinese Medicine Compound Baqia Danshen Liniment: Network Pharmacology, Molecular Docking, and Animal Model Insights

The study investigates the therapeutic effects of Compound Baqian Danshen Liniment (CBDL), a Traditional Chinese Medicine, on vitiligo. Using network pharmacology, molecular docking, and animal models, the research demonstrates that CBDL modulates key pathways related to immune response, melanogenesis, and oxidative stress. The active component luteolin shows strong binding to tyrosinase, promoting melanocyte activity and pigmentation. In vitiligo-affected mice, CBDL treatment led to significant skin improvement and hair follicle regeneration. Additionally, CBDL reduced inflammatory cytokines and oxidative stress markers while enhancing tyrosinase levels. These findings suggest CBDL as a promising alternative treatment for vitiligo.