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This study found that the 11R-No. 10 peptide, delivered transdermally, significantly inhibited melanogenesis and produced a whitening effect in a UV-induced sun-tanning guinea pig model without cytotoxicity.

This study found that glycine treatment inhibited melanogenesis in B16F0 melanoma cells and reduced melanin content in C57BL/6J mice by down-regulating tyrosinase protein levels.

In this study, different types of catagen in the C57BL/6 mouse model exhibited varying effects on hair follicle melanocytes and melanin distribution, with spontaneous and dexamethasone-induced catagen showing pigment incontinence, while cyclophosphamide-induced catagen retained dendritic melanocytes but increased ectopic melanin.

Understanding genes can help diagnose and treat skin color disorders.

This study investigated novel genetic tools to manipulate hair follicle compartments in mice and found that altering dermal papilla genes can significantly impact hair pigmentation.

This study found that hair follicle melanocytes show increased age-related susceptibility to oxidative stress compared to epidermal melanocytes, which may contribute to the graying of hair.

This study found that endothelin-1 increases adhesion and chemotaxis of amelanotic melanocytes on fibronectin, laminin, and collagen IV, potentially through changes in the actin cytoskeleton.

This study found that normal human melanocytes can be protected from apoptosis through both PI 3-kinase/Akt-dependent and independent pathways, with insulin and TPA offering nearly complete protection.

This abstract contains navigation and subscription information for JAMA Dermatology and reports no new clinical findings.

This article reviews potential pathomechanisms of vitiligo, emphasizing membrane alterations involving cholesterol and cardiolipin, but reports no new clinical findings.

Hair graying may help prevent cancer by protecting stem cells.

This article discusses the challenges in hair follicle pigmentation research compared to epidermal melanocytes and highlights the limitations of relying on mouse models, but reports no new experimental findings.

This study demonstrates that melanocyte stem cells can be a source of melanoma in a mouse model, resembling human melanoma in both heterogeneity and gene signatures.

This report describes two cases of sustained hair repigmentation related to porphyria cutanea tarda, though the underlying mechanism remains unclear.

This study found that Notch signaling is crucial for maintaining proper melanocyte distribution and preventing premature differentiation in the melanocyte lineage within hair follicles.

This review highlights the possibility of safely altering hair color through innovative cosmetics by targeting key biological processes in hair follicles, using insights from mammalian pigmentation studies and drug-induced hair color changes as potential pathways.

This review discusses the processes of melanocyte stem cell quiescence and activation, focusing on their interaction with hair follicle stem cells, and highlights current research on hair graying mechanisms; it reports no new results.

This study found that synthetic melanin particles applied topically in mouse injury models improved wound healing, showing potential as a therapy for accelerated healing, including in human skin explants.

This study found that compromised antioxidant activity in gray hair follicles affects both mature melanocytes and their immature precursors, linked to down-regulation of melanogenesis-related genes.

This review discusses how the CRH/POMC systems may regulate human hair follicle pigmentation and highlights the concept of "self-similarity" in melanocortin systems at both local and systemic levels, without presenting new experimental results.

This study revealed that during fetal development, MITF and Mart-1 expressing melanocytes progress from the dermis to the epidermis and hair follicles, with MITF possibly marking follicular stem cells.

This study observed that skin pigmentation significantly attenuates bioluminescent signals in C57Bl/6 mice, complicating quantitative optical imaging and requiring consideration in experimental design.

This review summarizes the biological process of melanogenesis and evaluates natural skin-whitening treatments based on their mechanisms affecting melanin production, aiming to inform on the effects and awareness of skin-bleaching creams.

This study found that p21 is much more highly expressed in normal melanocytes compared to melanoma cells, suggesting a potential target for preventing melanoma progression through cell cycle repair processes.

This study found that Indian and Chinese black hair, with higher melanin content, resist photochemical degradation better than European hair, which has lower melanin levels, when exposed to dry, hot climates.

This study successfully cultured human fetal hair follicle-derived melanocytes, which showed high proliferative capabilities and unique morphological characteristics compared to adult-derived cells, potentially advancing hair disease research.

This study found that neonatal Regulatory T cells are crucial for maintaining PPARγ signaling in hair follicles, which supports melanocyte stem cell function and skin pigmentation during early postnatal development.

This study found that the cell of origin in mouse skin affects melanoma phenotype and response to therapies, despite the presence of the same genetic mutations.

Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.

This review provides an analysis of topical treatments with clinically proven efficacy for managing hyperpigmentation and concludes that the most effective approach is using combined therapies that target multiple aspects of skin pigmentation physiology.