Glycine Inhibits Melanogenesis in Vitro and Causes Hypopigmentation in Vivo

    January 2007 in “ Biological & pharmaceutical bulletin ”
    Masago Ishikawa, Ichiro Kawase, Fumio Ishii
    Image of study
    TLDR Glycine reduces skin pigmentation by lowering melanin production.
    The study demonstrated that glycine inhibited melanogenesis in B16F0 melanoma cells and hair follicle melanogenesis in C57BL/6J mice. Glycine treatment (1—16 mM) for 72 hours reduced α-MSH-induced melanogenesis in a concentration-dependent manner without affecting cell proliferation. In mice, glycine (1250 or 2500 mg/kg) administered for 5 days prevented decreases in L* and C* values and reduced tyrosinase protein levels and melanin content in the skin. These effects were similar to those observed with kojic acid and hydroquinone treatments. The findings suggested that glycine's hypopigmenting effect was due to the down-regulation of tyrosinase protein levels.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 38 results

      community Vinpocetine and topical Minoxidil

      in Minoxidil 2 years ago
      A 25-year-old is using vinpocetine to enhance the absorption of topical Minoxidil for hair loss. They also use a hair tonic and supplement with Glycine, Taurine, Creatine, and Citrulline.

      community This serum outperformed Minoxidil in a recent study. Please debunk

       23 upvotes 6 years ago
      A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

      community Getting hit hard by the shed….

      in Progress Pictures  88 upvotes 1 year ago
      A user is experiencing significant hair shedding after starting a treatment regimen of 1mg oral finasteride, 3mg oral minoxidil, 2.5mg biotin, and vitamins. Despite the shedding, they remain optimistic and plan to continue the treatment for a year before making any conclusions.

      community My results & the importance of nutrition on hair health and growth. (M/30, Diffuse Thinner)

       7 upvotes 6 years ago
      A 30-year-old man with diffuse hair thinning shared his hair regrowth regimen, which includes increasing Vitamin D intake, taking oral castor oil, using a dermapen, and various supplements like Glycine, K2, Vitamin E, Vitamin C, Aspirin, Sodium Bicarbonate, and a multivitamin. He also mentioned inconsistent use of Minoxidil, Peppermint Oil, Zix, and topical Castor Oil, and negative side effects from Finasteride, RU58841, and Nizoral.

    Similar Research

    5 / 1000+ results