Glycine Inhibits Melanogenesis in Vitro and Causes Hypopigmentation in Vivo

    January 2007 in “ Biological & pharmaceutical bulletin ”
    Masago Ishikawa, Ichiro Kawase, Fumio Ishii
    Image of study
    TLDR Glycine reduces skin pigmentation by lowering melanin production.
    The study demonstrated that glycine inhibited melanogenesis in B16F0 melanoma cells and hair follicle melanogenesis in C57BL/6J mice. Glycine treatment (1—16 mM) for 72 hours reduced α-MSH-induced melanogenesis in a concentration-dependent manner without affecting cell proliferation. In mice, glycine (1250 or 2500 mg/kg) administered for 5 days prevented decreases in L* and C* values and reduced tyrosinase protein levels and melanin content in the skin. These effects were similar to those observed with kojic acid and hydroquinone treatments. The findings suggested that glycine's hypopigmenting effect was due to the down-regulation of tyrosinase protein levels.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 22 results

      community Methionine? Glycine?

       6 upvotes 8 years ago
      The conversation discusses the potential benefits and risks of using Methionine and Glycine for hair loss, with concerns about cancer risk if not balanced properly. The user seeks opinions on these amino acids for hair health and overall benefits.

      community Vinpocetine and topical Minoxidil

      in Minoxidil 1 year ago
      A 25-year-old is using vinpocetine to enhance the absorption of topical Minoxidil for hair loss. They also use a hair tonic and supplement with Glycine, Taurine, Creatine, and Citrulline.

      community My results & the importance of nutrition on hair health and growth. (M/30, Diffuse Thinner)

       6 upvotes 5 years ago
      A 30-year-old man with diffuse hair thinning shared his hair regrowth regimen, which includes increasing Vitamin D intake, taking oral castor oil, using a dermapen, and various supplements like Glycine, K2, Vitamin E, Vitamin C, Aspirin, Sodium Bicarbonate, and a multivitamin. He also mentioned inconsistent use of Minoxidil, Peppermint Oil, Zix, and topical Castor Oil, and negative side effects from Finasteride, RU58841, and Nizoral.

    Similar Research

    5 / 723 results