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GlossaryMerkel cell polyomavirus (MCPyV)

virus linked to rare skin cancer, Merkel cell carcinoma

Merkel cell polyomavirus (MCV or MCPyV) is a virus that has been linked to a rare and aggressive form of skin cancer known as Merkel cell carcinoma. Discovered in 2008, this virus is found in the majority of Merkel cell carcinoma tumors, suggesting a strong association between the virus and the development of this cancer.

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research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

133 citations, May 2016 in “Cell Host & Microbe”

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

research Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice

14 citations, February 2022 in “The Journal of clinical investigation/The journal of clinical investigation”

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.

research Molecular Mechanisms of Viral Oncogenesis in Humans

141 citations, August 2018 in “Nature Reviews Microbiology”

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

research Transduction-Induced Overexpression of Merkel Cell T Antigens in Human Hair Follicles Induces Formation of Pathological Cell Clusters with Merkel Cell Carcinoma-Like Phenotype

5 citations, August 2021 in “Experimental dermatology”

Overexpressing Merkel cell virus proteins in human hair follicles can create clusters of cells that resemble Merkel cell cancer.

research Low Versus High Fluence Light-Induced Hair Removal: How Hair Follicle Ex Vivo Studies Translate Into Clinical Results

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Higher fluence in hair removal damages hair follicles more, while lower fluence mimics natural hair regression, with long-term IPL treatments effectively reducing hair.

MmuPV1 Infection and Tumor Development in T Cell-Deficient Mice Prevented by Passively Transferred Hyperimmune Sera from Normal Congenic Mice Immunized with MmuPV1 Virus-Like Particles

research MmuPV1 Infection and Tumor Development in T Cell-Deficient Mice Prevented by Passively Transferred Hyperimmune Sera from Normal Congenic Mice Immunized with MmuPV1 Virus-Like Particles

14 citations, January 2016 in “Experimental and molecular pathology”

Giving immune serum from vaccinated mice to mice without T cells prevents infection and tumor growth.

Anti-Basal Cell Carcinoma Efficacy of a Topical Hedgehog Inhibitor Without Adverse Effects in Gorlin Syndrome Patients in a Phase 2 Randomized Controlled Trial

research Anti-Basal Cell Carcinoma Efficacy of a Topical Hedgehog Inhibitor Without Adverse Effects in Gorlin Syndrome Patients in a Phase 2 Randomized Controlled Trial

1 citations, April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

research Viral-Associated Trichodysplasia Spinulosa: A Case with Electron Microscopic and Molecular Detection of the Trichodysplasia Spinulosa-Associated Human Polyomavirus

71 citations, January 2011 in “Journal of cutaneous pathology”

A rare skin condition was confirmed to be associated with a specific virus in a young girl.