LRIG1 as a Positive Prognostic Marker in Merkel Cell Carcinoma and Expression of Epithelial Stem Cell Markers

    July 2021 in “ Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin ”
    Benjamin Sundqvist, Harri Sihto, Maria von Willebrand … Virve Koljonen
    Studysummary This study found that the expression of LRIG1 in Merkel cell carcinoma tumors was associated with improved overall and cancer-specific survival.
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    Research cited in this study 5

    1. Evidence of Proliferative Activity in Human Merkel Cells: Implications in the Histogenesis of Merkel Cell Carcinoma Archives of Dermatological Research · 2018
    2. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    3. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    4. Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage Journal of Cell Science · 1996
    5. Characterization of Hair Follicle Bulge in Human Fetal Skin: The Human Fetal Bulge Is a Pool of Undifferentiated Keratinocytes Journal of Investigative Dermatology · 1995