Evidence of Proliferative Activity in Human Merkel Cells: Implications in the Histogenesis of Merkel Cell Carcinoma
November 2018
in “
Archives of Dermatological Research
”
Research cited in this study
15 / 15 results
research Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles
This study provides evidence that Cyclosporine A inhibits catagen development in human hair follicles, suggesting different underlying mechanisms from those observed in rodent studies.
research Mapping the Expression of Epithelial Hair Follicle Stem Cell-Related Transcription Factors LHX2 and SOX9 in the Human Hair Follicle
In this study, LHX2 and SOX9 were found to mark distinct epithelial progenitor cell populations within human hair follicles, suggesting roles in maintaining the hair follicle epithelium.
research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges
This review examines current knowledge on human epithelial hair follicle stem cells, their markers, and outlines challenges in translating findings from murine studies to human research, but does not report new experimental results.
research Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers
Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.
research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells
This study found that androgenetic alopecia may involve a defect in the conversion of hair follicle stem cells to progenitor cells, as demonstrated by a reduced presence of progenitor cells in bald scalp samples.
research Nonviral In Situ Green Fluorescent Protein Labeling and Culture of Primary, Adult Human Hair Follicle Epithelial Progenitor Cells
This study reported that GFP labeling driven by the K15 promoter enables visualization and selection of stem cells in adult human scalp hair follicles for further analysis and manipulation.
research Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation
This study found that C8/144B antibody exclusively binds to the hair follicle bulge and not the epidermal stratum basale, with cytokeratin 19 serving as a key marker of certain basal keratinocytes that decrease with age.
research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells
This study found that bulge cells marked by CD200+ in human hair follicles show high colony-forming efficiency, suggesting successful enrichment of keratinocyte stem cells.
research Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells
This study found that rat whisker follicle stem cells can be expanded in culture and transplanted to form functional hair follicles, demonstrating their multipotency and potential for regenerative medicine.
research Cytokeratins as Markers of Follicular Differentiation
This study found that trichoblastomas and nodular basal cell carcinomas have similar cytokeratin expression patterns, indicating differentiation towards the outer root sheath epithelium.
research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.
research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis
In this study, researchers found that hair follicle stem cells in mice can generate both hair follicle and epidermis cells, highlighting their potential bipotency.
research Merkel Cells in Hyperplastic and Neoplastic Lesions of the Skin
This study found that Merkel cell hyperplasia is specific to certain skin diseases and not related to general epidermal proliferation.
research Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage
This study found that keratin 19 may be a marker for skin stem cells, helping to characterize these cells in different conditions and potentially explaining variations in healing rates between children and adults.
research Epithelial Skirt and Bulge of Human Facial Vellus Hair Follicles and Associated Merkel Cell-Nerve Complex
Merkel cells are abundant in facial vellus hair follicles, especially during the anagen phase.
Similar Research
5 / 1000+ resultsresearch Merkel Cells in Hyperplastic and Neoplastic Lesions of the Skin
This study found that Merkel cell hyperplasia is specific to certain skin diseases and not related to general epidermal proliferation.
research Transduction‐induced overexpression of Merkel cell T antigens in human hair follicles induces formation of pathological cell clusters with Merkel cell carcinoma‐like phenotype
This study suggests that Merkel cell polyomavirus T antigen-positive cells resembling Merkel cell carcinoma may originate from epithelial cells in human hair follicles, potentially informing future transgenic mouse models for this cancer.
research Localization of Merkel cells at hairless and hairy human skin sites using keratin 18
This study localized Merkel cells in human skin, finding them in the basal layer of glabrous skin at palms and soles, and in the interfollicular epidermis and isthmus region of hair follicles.
research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection
In this study, human dermal fibroblasts were identified as natural host cells that support productive Merkel cell polyomavirus infection, and the MEK antagonist trametinib was introduced as an effective inhibitor to control the virus.
research LRIG1 is a positive prognostic marker in Merkel cell carcinoma and Merkel cell carcinoma expresses epithelial stem cell markers
This study found that the expression of LRIG1 in Merkel cell carcinoma tumors was associated with improved overall and cancer-specific survival.