14 citations,
June 2022 in “Stem cell reports” The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.
3 citations,
May 2022 in “Oncogene” Vav2 and Vav3 proteins help control skin stem cell numbers and activity in both healthy and cancerous cells.
214 citations,
April 2017 in “Cell” Different small areas within hair follicles send specific signals that control what type of cells stem cells become.
32 citations,
February 2019 in “eLife” BMP signaling is essential for the development of touch domes.
Male goat smell increases reaction in young female goats' noses but doesn't cause them to start puberty early.
12 citations,
April 2019 in “Nature protocols” Scientists created a functional 3D skin system from stem cells that can be transplanted into wounds.
91 citations,
December 2000 in “The journal of cell biology/The Journal of cell biology” Scientists successfully created mouse hair proteins in the lab, which are stable and similar to natural hair.
2 citations,
June 2023 in “Journal of cell science” Mutations in iRhom2 affect hair and skin in mice and are linked to esophageal cancer, with ADAM17 playing a crucial role.
115 citations,
September 2000 in “The Lancet” Early hair loss may indicate risk of insulin resistance.
A 70-year-old man with skin cancer on both sides of his forehead was treated with surgery and cryotherapy, highlighting the need for early detection and prevention.
75 citations,
October 2016 in “Genes & Development” Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.
May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” Primary cilia affect the size and oil production of eye glands but not the oil's makeup.
July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Neutrophil extracellular traps slow down hair follicle healing after injury.
Fat tissue can potentially treat a common form of hair loss called androgenic alopecia.
16 citations,
February 2022 in “Science Advances” Follistatin and LIN28B together improve the ability of inner ear cells in mice to regenerate into hearing cells.
Certain gene variations and different levels of BDNF and CRH hormones are linked to vitiligo.
18 citations,
November 1994 in “Histochemical Journal” The enzyme PST is found in developing human kidneys and helps with detoxification and development.
Different stem cells are key for hair growth and health, and understanding their regulation could help treat hair loss.
January 2022 in “Figshare” Autophagy helps mouse glands stay healthy, prevents early aging, and maintains their oil and scent production.
3 citations,
March 2019 in “Post Reproductive Health” Testosterone replacement can help menopausal women with various symptoms, but should be used carefully and is not yet officially licensed in the UK for women.
116 citations,
August 2010 in “Nature” Scientists turned rat thymus cells into stem cells that can help repair skin and hair.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists created skin-like structures from stem cells that include features like hair and sweat glands.
2 citations,
December 2022 in “Journal of Biochemistry and Molecular Biology” Organoids created from stem cells are used to model diseases, test drugs, and develop personalized and regenerative medicine.
31 citations,
September 2013 in “Stem Cells” Smad1 and Smad5 are essential for hair follicle development and stem cell sleepiness.
6 citations,
July 2023 in “Nature cell biology” SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.
15 citations,
February 1999 in “The anatomical record” Some mutant mice have hair with abnormal cross-linking, mainly in the cuticle, not affecting other hair parts.
21 citations,
January 2018 in “Journal of Investigative Dermatology” Rats can't grow new hair follicles after skin wounds, unlike mice, due to differences in gene expression and response to WNT signaling.
April 2024 in “Journal of Cytology” A rare skin tumor with bone formation was successfully removed without recurrence.
1 citations,
April 2012 in “Informa Healthcare eBooks” Some medications for inflammation can cause a condition with scalp rashes and hair loss, often linked to Crohn's disease, and may require treatment changes to prevent permanent hair loss.
9 citations,
March 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” Ectodysplasin signaling is crucial for skin appendage development, requiring specific doses and durations.