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Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.

Hirsutism is excessive hair growth in women often caused by polycystic ovarian syndrome, and identifying the cause is important for managing associated health risks.

High-frequency ultrasonography is a useful but underused tool in dermatology for assessing skin cancers, monitoring diseases, and evaluating treatments.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Cancer development is like natural selection, involving mutated cells and environmental factors.

Some drugs can cause hair loss, and stopping these drugs often leads to hair regrowth.

Epidermal stem cells could lead to new treatments for skin and hair disorders.

Nanotechnology in dermatology shows promise for better drug delivery and treatment effectiveness but requires more safety research.

Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.

Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.

Tcf3 helps cells move and heal wounds by controlling lipocalin 2.

TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.

Dermatologists are more accurate than general practitioners in diagnosing skin conditions, especially skin cancer.

Removing a cat's pancreatic cancer can temporarily reverse hair loss caused by the disease.

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.

Recognizing oral symptoms can help diagnose and treat blood and nutritional diseases early.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Seborrhea in Parkinson's disease may be linked to hormones, not autonomic impairment.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

*Acorus calamus* has many medicinal benefits but needs more safety research.

Gefitinib can cause skin problems, diarrhea, and nausea, but rarely causes severe lung disease or hair loss.

Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.