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90-120 / 1000+ resultsresearch Decision letter for “Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls”
research Author response for “Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls”
research Decision letter for “Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls”
research Review for “Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls”
research Review for “Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls”
research Review for “Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls”
research Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment
This review highlights that unresolved inflammation is a major issue in diabetic foot ulcers and discusses emerging biomaterials-based strategies to modulate the inflammatory response, potentially aiding in tissue regeneration and healing in these chronic wounds.
research EGCG-Biotin-Pal-GHK composition modulates TGF-β and BMP pathways in scalp microenvironment for treating stress-induced alopecia
research Synergistic antioxidant-antimicrobial-immunomodulatory self-healing “radical sponge” hydrogel for diabetic wound regeneration via microenvironment reprogramming mediated by coordinated MAPK suppression and PI3K-AKT activation
The hydrogel helps heal diabetic wounds by combining antibacterial, antioxidant, and immune-boosting effects.
research Redox-Responsive Polymer Dot Nanozymes Coordinate Exosome-Mediated Cutaneous Regeneration via Laser-Modulated Microenvironment Remodeling
This study developed a novel regenerative platform using nanozyme-enabled materials combined with exosomes and laser stimulation to enhance wound healing in a mouse model, which more effectively regulated reactive oxygen species and improved early angiogenesis and collagen organization compared to conventional methods.
research Synergistic Antioxidant-Antimicrobial-Immunomodulatory Self-Healing “Radical Sponge” Hydrogel for Diabetic Wound Regeneration via Microenvironment Reprogramming Mediated by Coordinated MAPK Suppression and PI3K-AKT Activation
research Synergistic Antioxidant-Antimicrobial-Immunomodulatory Self-Healing “Radical Sponge” Hydrogel for Diabetic Wound Regeneration via Microenvironment Reprogramming Mediated by Coordinated MAPK Suppression and PI3K-AKT Activation
research Synergistic Antioxidant-Antimicrobial-Immunomodulatory Self-Healing “Radical Sponge” Hydrogel for Diabetic Wound Regeneration via Microenvironment Reprogramming Mediated by Coordinated MAPK Suppression and PI3K-AKT Activation
research Engineered Bilayer Hydrogel with Spatiotemporal Drug and Oxygen Delivery for Diabetic Wound Microenvironment Reprogramming
In this study, researchers developed a responsive bilayer hydrogel for diabetic wounds that delivers drugs and oxygen in sync with healing stages, achieving a 99.1% wound closure rate in 14 days by integrating anti-inflammatory, antibacterial, and anti-fouling functions.
research Hydrogel Microneedles Loaded with bFGF and PVP-Modified Iridium Nanoparticles Improve Follicular Microenvironment for Androgenetic Alopecia Treatment
Hydrogel microneedles with special nanoparticles and growth factor improve hair growth better than minoxidil for hair loss treatment.
research Engineered Exosomes Biopotentiated Hydrogel Promote Hair Follicle Growth via Reprogramming the Perifollicular Microenvironment
In a mouse model of androgenetic alopecia, this study found that a novel hydrogel containing minoxidil-incorporated engineered exosomes (Gel@MNs) enhanced hair regeneration more effectively than conventional minoxidil, increasing hair follicle number and size while reducing skin irritation.
research All-in-one polysaccharide hydrogel with resistant vascular burst pressure and cooperative wound microenvironment regulation for fatal arterial hemorrhage and diabetic wound healing
This study reports that beta-glucan hybrid hydrogels, reinforced with laponite nanoclay, showed promising results in rat models for managing hemorrhage and diabetic wound healing by enhancing hemostasis, reducing inflammation, and promoting faster wound closure and tissue regeneration.
research In situ formed fluorescent gold nanoclusters inhibit hair follicle regeneration in oxidative stress microenvironment via suppressing NFκB signal pathway
In this study, researchers demonstrated that zero valence fluorescent gold nanoclusters can be biosynthesized in damaged skin and inhibit hair follicle regeneration by affecting the NFκB inflammatory response pathway, suggesting potential as a treatment for hypertrichosis related to skin injury.
research 584 Dandruff is associated with perturbations of hair follicle immune privilege, and the infundibular and epidermal immune microenvironment
This study observed that dandruff is linked to a weakened immunoprivilege in hair follicles, with reduced Langerhans cells and increased epidermal CD4+ and CD8+ T cell infiltration.
research 1408 INDUCTION OF SECRETED WNT FACTOR WISP1/CCN4 BY HUMAN PROSTATE STROMAL CELLS BY MICROENVIORNMENTAL HYPOXIA
Human prostate cells produce more WISP1/CCN4 when there's not enough oxygen.
research Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment
This study found that Myc activation in mouse epidermis impairs keratinocyte adhesion and motility by downregulating extracellular matrix and cytoskeleton proteins, affecting hair lineage differentiation.
research Altered FGF expression profile in human scalp-derived fibroblasts upon WNT activation: implication of their role to provide folliculogenetic microenvironment
In this study, researchers found that WNT activation influenced FGF expression in human scalp-derived fibroblasts, with mouse model results showing FGF9 increased hair follicle number and diameter, while FGF7 reduced diameter.
research Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice
This study found that IL-1α promotes hair follicle regeneration and stem cell activation in an age-dependent manner by modulating inflammatory cells and oxidative stress in mice.
research A bioactive, multifunctional hydrogel dressing from sugarcane molasses extract promotes scarless healing in chronic wounds via microenvironment-responsive drug release
research Fermented Morinda citrifolia extract stimulates hair growth by promoting dermal papilla cell proliferation and modulating the follicular microenvironment
This study found that fermented Morinda citrifolia extract enhances the viability and cycle progression of human dermal papilla cells and promotes hair growth through Wnt/β-catenin signaling activation, suggesting its potential as a therapeutic candidate for alopecia.
research Ionic liquid–coated Eudragit RS nanoparticles for topical delivery of honokiol to remodel the hair follicle microenvironment in androgenic alopecia
research Cinnamomum burmannii Leaves-Derived Carbon Dots Promote Angiogenesis and Stimulate Hair Follicle Regeneration by Reshaping the Microenvironment of Hair Follicles
This study developed a novel treatment method using carbon dots from Cinnamomum burmannii leaves, which improved hair regeneration and thickness in an AGA mouse model by promoting cell proliferation, angiogenesis, and reducing inflammation through multiple signaling pathways.
research 068 Pathogenic Th17 cells, CD8+CD69+CD49a- tissue-resident memory T cells and common γ chain receptor + natural killer cells express more IL-17, compared to IFN-γ, under the foxp3+ memory regulatory T cells-depleted microenvironment in patients with chronic alopecia areata
This research explored the roles of various T cell types in chronic alopecia areata, finding that increased severity of lesions and hair loss may be linked to decreased lesional Foxp3+ Tregs, with a notable role for IL-17 and Th17 lymphocytes in the pathological process.
research Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4
This study found that aging mice experience slower and more fragmented hair cycle waves, but transplanting aged skin to a young host can partially restore hair cycling, implicating extracellular factors.