Facile Strategy for Gelatin-Based Hydrogel with Multifunctionalities to Remodel Wound Microenvironment and Accelerate Healing of Acute and Diabetic Wounds
November 2023
in “
International Journal of Biological Macromolecules
”
gelatin-based hydrogel QCN@Gel-Zr zirconium gelatin quercetin antibacterial free radical–scavenging cellular proliferation oxidative stress inflammatory expression biocompatibility wound healing angiogenesis collagen deposition hair follicle regeneration cytotoxicity gelatin hydrogel Zr4+ QCN antioxidant inflammation reduction biocompatible healing blood vessel formation collagen growth hair growth non-toxic
TLDR The gelatin-based hydrogel helps heal acute and diabetic wounds faster by improving healing conditions.
The study presents a simple method to create a gelatin-based hydrogel (QCN@Gel-Zr) for diabetic wound treatment. The hydrogel is made by combining zirconium (Zr4+), gelatin, and quercetin (QCN). The addition of QCN improved the hydrogel's mechanical, injection, and adhesive performance, and also gave it antibacterial and free radical–scavenging abilities. These properties promoted cellular proliferation and migration, protected against oxidative stress, and reduced inflammatory expression. The hydrogel was tested on in vivo models of acute and chronic diabetic skin wounds, where it showed biocompatibility and the ability to promote wound healing. The hydrogel also promoted angiogenesis, collagen deposition, and hair follicle regeneration without detectable cytotoxicity. This research demonstrates the potential of gelatin-based hydrogel for diabetic wound repair.
