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Accurate quantitative bioanalysis using LC-MS/MS is challenging due to matrix effects, but using internal standards and new methods like in-sample calibration could improve results.

Hair testing is a reliable method for detecting workplace drug use when done with proper sample preparation and confirmation.

Segmental hair analysis can track testosterone over time but needs adjustments for sex, hair color, and washing frequency.

Hair analysis can somewhat track past testosterone levels but is influenced by factors like hair washing, growth rate, sex, and hair color.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Researchers identified new compounds in Platycladi Cacumen and found variations in its flavonoid content, which could aid in its quality control.

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

Intravaginal testosterone cream improves sexual satisfaction and reduces vaginal discomfort in postmenopausal women on breast cancer treatment without affecting hormone levels.

Many young Italian women have hyperandrogenic disorders like PCOS, which are linked to age, body weight, and insulin resistance.

Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.

Researchers developed a method to measure plant compounds in rat blood and found they are quickly absorbed and eliminated within 36 hours.

Ketoconazole increases finasteride's effectiveness and lifespan in the body.

The trial showed that a new under-the-tongue treatment for severe hair loss was somewhat effective in a small group of people.

Finasteride treatment changes urine metabolomics and steroid signatures, potentially monitoring effectiveness but may cause sexual side effects.

Finasteride affects SRD5A2 gene pattern, possibly causing lasting side effects.

Using 5-butylpicolinate esters improves the sensitivity and reliability of detecting testosterone and dihydrotestosterone in saliva.

Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.

Prenatally androgenized ewes can model increased hair diameter in women with PCOS.

Optimal long-acting finasteride injection dose found: 16.8 mg, effective for one month.

Hair cortisol and cortisone levels may affect how work stress influences depression in Chinese fishermen.

A new method was created to analyze certain chemicals in the urine of alopecia areata patients, revealing they have higher metanephrine content. This method can also be used for other related diseases.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

Men with advanced liver disease and high oestrone and low testosterone levels have worse health outcomes.

15-lipoxygenase helps keep skin healthy by reducing inflammation.

Hair analysis is better than urine and blood for detecting past drug use.

Most women with depression in the study had low vitamin D levels.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.