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New CRISPR/Cas9 variants and nanotechnology-based delivery methods are improving cancer treatment, but choosing the best variant and overcoming certain limitations remain challenges.

Nanomaterials in biomedicine can improve treatments but may have risks like toxicity, needing more safety research.

Cicatricial alopecia, a permanent hair loss condition, is mainly caused by damage to specific hair follicle stem cells and abnormal immune responses, with gene regulator PPAR-y and lipid metabolism disorders playing significant roles.

The document recommends using both clinical evaluation and various measurement methods to assess skin greasiness, considering factors like temperature and hormones.

Nanotechnology shows promise for better drug delivery and cancer treatment.

Oral retinoids are effective for various skin conditions but have side effects and should not be used during pregnancy.

Liposomes show promise for delivering CRISPR for gene editing but face challenges like delivery efficiency and safety concerns.

Multi-omics techniques help understand the molecular causes of androgenetic alopecia.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

Hormonal therapy is a treatment option for acne, the only medical treatment for hirsutism, and the most promising for androgenetic alopecia.

Nanostructured lipid carriers are effective for treating hyperpigmentation in women aged 30-40.

Primary cilia affect the size and oil production of eye glands but not the oil's makeup.

The guidelines suggest lifestyle changes, diet adjustments, and personalized medication to manage dyslipidemia and reduce heart disease risk.

Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

A device was made in 2008 to measure hair loss severity. Other findings include: frizzy mutation in mice isn't related to Fgfr2, C/EBPx marks preadipocytes, Cyclosporin A speeds up hair growth in mice, blocking plasmin and metalloproteinases hinders healing, hyperbaric oxygen helps ischemic wound healing, amniotic membranes heal wounds better than polyurethane foam, rhVEGF165 from a fibrin matrix improves tissue flap viability and induces VEGF-R2 expression, and bFGF enhances wound healing and reduces scarring in rabbits.

Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.

Photobiomodulation therapy using red and near-infrared light can reduce inflammation and aid in healing various conditions.

Hormone therapy is safe and effective for transgender adults, but requires regular monitoring and mental health support.

The document concludes that gender-affirming treatments are essential for transgender individuals and outlines safe hormone therapy practices.

The document concludes that understanding hair biology is key to treating hair disorders, with gene therapy showing potential as a future treatment.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.

Topical treatments can deliver active molecules to skin stem cells, potentially helping treat skin and hair disorders, including skin cancers and hair loss.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Microencapsulation helps protect and track therapeutic cells, showing promise for treating various diseases, but more work is needed to improve the technology.

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

The Polish medical societies have redefined metabolic syndrome and recommend lifestyle changes, certain medications, and possibly bariatric surgery for treatment. They also discuss managing related health conditions.