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A 12-year-old boy with PAIS successfully developed male characteristics using high-dose testosterone and anastrozole.

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.

The document concludes that the androgen receptor's structure and function are complex, affecting how it regulates genes and is involved in diseases like prostate cancer.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Mice without the IL-6 gene had more hair growth after injury due to higher activity of a related protein, Stat3.

The research identified genes that explain why some sheep have curly wool and others have straight wool.

The study found that certain mutations in the vitamin D receptor can cause rickets and potentially affect hair growth.

Caribine from traditional Chinese medicine may help treat hair loss.

Riboflavin 5′-phosphate (FMN) shows potential for treating androgen-related conditions but may be limited in treating prostate cancer.

TNC+ fibroblasts play a key role in skin inflammation by interacting with T cells.

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

Mutations in the androgen receptor gene cause different levels of androgen insensitivity, making it hard to create simple tests for the condition.

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

RANK-RANKL signaling is essential for hair growth and skin health.

Future research on ectodysplasin should explore its role in diseases, stem cells, and evolution, and continue developing treatments for genetic disorders like hypohidrotic ectodermal dysplasia.

New treatments for alopecia areata may target specific immune cells and pathways involved in hair loss.

Activating Notch signaling can kill basal cell carcinoma cells.

Analog 23 is a promising compound for prostate cancer treatment.

A specific signal from hair cells controls the tightening of the surrounding muscle, which is necessary for hair shedding.

Vδ1+ T-cells in the skin contribute to hair loss in alopecia areata and could be targeted for treatment.

Blocking CISD1 reduces hearing loss from cisplatin in mice.

Too much IKZF1 and Ikaros protein may cause alopecia areata.

Wnt-signaling is regulated differently in skin cells and immune responses during wound healing.

Hair follicle stem cells prevent melanocyte stem cells from differentiating by controlling retinoic acid levels.

Sonic hedgehog signaling is needed for the development of touch-receptor cells in the skin, and the loss of Polycomb repressive complex 2 can lead to more of these cells.

Activating TLR3 helps improve skin and hair follicle regeneration after wounds.

After skin injury, adult mice can grow new hair follicles, and this process can be increased or stopped by manipulating Wnt signals.

Hair follicle cells help protect against immune attacks by regulating T-cell activity.

PPAR alpha may help in hair growth and could be a target for treatment.