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New drugs targeting the JAK-STAT pathway show promise for treating inflammatory skin diseases.

The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Fibromodulin treatment helps reduce scarring and improves wound healing by making it more like fetal healing.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Consider benefits and risks of new alopecia treatments for safety.

COVID-19 might worsen symptoms and progression of benign prostatic hyperplasia, possibly due to inflammation and metabolic disturbances in the prostate gland. More research is needed to confirm this.

Skin health and repair depend on the signals between skin stem cells and their surrounding cells.

IL-1 family cytokines are crucial for skin defense and healing, but their imbalance can cause skin diseases.

Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

Mutations in iRhom2 affect hair and skin in mice and are linked to esophageal cancer, with ADAM17 playing a crucial role.

Swedish men with the E213 A-allele of the androgen receptor have a lower risk of prostate cancer.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

A patient with a larger than usual genetic mutation had a broader range of symptoms for a muscle disease.

The document concludes that careful design of genetic fate mapping experiments is crucial for accurate cell lineage tracing in mice.

The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.

Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.

Different light affects cell functions and can help treat skin conditions.

Hair follicle stem cells help skin heal and grow during stretching.

Tacrolimus causes fewer acute rejections than cyclosporin A in kidney transplants but doesn't necessarily improve kidney function after one year; cardiovascular risks and side effects vary between the two drugs.

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

Tissue environment greatly affects the unique epigenetic makeup of regulatory T cells, which could impact autoimmune disease treatment.

Delta-opioid receptors affect skin cell circadian rhythms, possibly impacting wound healing and cancer.

Understanding how baby skin heals without scars could help develop treatments for adults to heal wounds without leaving scars.