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This review suggests that most mutations in the SRD5A2 gene show no clear genotype-phenotype correlation in 5-α-Reductase deficiency, although mutation location affects severity.

The conclusion is that CD90 is not a specific marker for fibroblast subtypes and better methods are needed to identify them.

This study found that both finasteride and dutasteride act as slow, time-dependent inhibitors of steroid 5α-reductase type II, with dutasteride being more efficient, influenced by the enzyme's genetic variants.

This study found that IFN-γ plays a critical role in T cell activation and the pathogenesis of alopecia areata in C3H/HeJ mice.

The authors concluded that increased expression of the HSD11B1 gene in adipose tissue correlates with obesity markers and predicts insulin resistance, but this association is independent of polycystic ovary syndrome when adiposity is controlled for.

This study found no significant associations between the polymorphisms of SRD5A1 and SRD5A2 genes and androgenetic alopecia, clinical types of baldness, or response to finasteride in Koreans.

This review discusses the historical and potential medical uses of Cyperus rotundus rhizomes, but reports no new clinical results and emphasizes the need for further study on its pharmacognostic properties.

This study found that elastic liposomes enhanced skin delivery of genistein in haired skin compared to conventional liposomes, but showed decreased effectiveness in hairless skin.

This study found that neurotrophin-4 regulates Cav3.2 T-current expression in D-hair neurons via TrkB receptor activation, highlighting its role in mechanosensitive function.

This review discusses the potential therapeutic role of the edible plant Solanum nigrum for managing COVID-19 symptoms and post-COVID complications based on in silico docking and pharmacological studies, but reports no new clinical results.

This study found that variations in sleep patterns, free testosterone, and 5-alpha-reductase type 1 activity are associated with changes in sebum excretion in women, which may contribute to variability in acne studies.

The researchers reported that keratin 33A is a structural protein specific to goat cashmere hair, with increased winter expression in high-cashmere-producing breeds.

This article describes how HIV-related skin disorders vary in presentation among pigmented skin types and highlights challenges in their diagnosis due to atypical disease manifestations.

This study optimized the reaction conditions for the stereoselective hydrogenation of a compound used in manufacturing finasteride and dutasteride, improving the selectivity for the desired isomer.

This review discusses the ethnobotanical use and bioactivity of Eclipta prostrata, highlighting its potential in treating various conditions and linking its effects to secondary metabolites.

This study found that Wet-type Age-Related Macular Degeneration patients had higher oxidative stress and HMGB-1 levels compared to healthy controls, suggesting a link to increased tissue inflammation and necrosis.

This review discusses the effects of dietary protein and its components on cholesterol, essential fatty acids, and possible health consequences, but presents no new clinical findings.

This study observed that Biota orientalis L. leaf extract may promote hair growth and suppress sebum production in human cells, suggesting potential benefits for hair restoration.

This study found that women with PCOS had significantly elevated plasma levels of PAI-1, which correlated with insulin resistance and obesity.

Fermentation of Finasteride with Ocimum sanctum L. creates new metabolite that inhibits tyrosinase.

In this case study, a 68-year-old woman was diagnosed with central diabetes insipidus and hypothalamic hypopituitarism due to a Rathke's cleft cyst.

This study examines the use of emulgel-based systems as drug delivery vehicles for hydrophobic medications, noting their potential benefits in dermatological applications due to properties like easy spreadability, non-greasy texture, and prolonged shelf life.

This review examines the traditional uses and biological activities of Glycyrrhiza glabra in Ayurveda, but reports no new clinical results; the authors identify a gap in evidence supporting its medicinal potential.

In this case report, a girl with autoimmune polyglandular syndrome type 1 experienced stabilized disease and reversal of alopecia universalis after treatment with glucocorticoids and methotrexate.

This case study highlights the complexity of managing autoimmune polyglandular syndrome type 1, emphasizing the need for thorough clinical history, high suspicion for early diagnosis, and continuous long-term follow-up.

In this study, researchers developed a dissolvable microneedle patch combining HA-TEMPO and Portulaca oleracea L.-derived nanoparticles, which effectively reduced oxidative stress and inflammation in an atopic dermatitis model while restoring immune balance, suggesting a promising treatment strategy.

This study found that combining sorafenib with Platycladus orientalis leaf extract effectively suppressed cervical cancer cell growth by increasing tumor suppressor gene expression and reducing anti-apoptotic gene expression, suggesting a potential rationale for further clinical trials.

This study reported that Hibiscus syriacus L. extracts, especially the ethanolic version, significantly reduced blood glucose and improved lipid profiles in diabetic rats, suggesting potential anti-diabetic benefits.

This case report discusses a 27-month-old girl with vitamin D-dependent rickets type II, who showed minor improvement in skeletal features and alopecia after high-dose oral calcium and vitamin D3 treatment.

This review summarizes the biological process of melanogenesis and evaluates natural skin-whitening treatments based on their mechanisms affecting melanin production, aiming to inform on the effects and awareness of skin-bleaching creams.