Rickets with Alopecia Signals Vitamin D Dependent Rickets Type II

In a case report from 2015, a 27-month-old female child with Vitamin D-dependent rickets type II, a rare autosomal recessive disorder, was presented. The child exhibited classical rachitic changes, a very high level of 25-hydroxy Vitamin D, 1,25 (OH)2D, and a markedly elevated serum Alkaline phosphatase. Despite being prescribed a very high dose of oral calcium and vitamin D3, only minor improvements were observed in her skeletal features and alopecia. This case emphasizes the importance for physicians to consider Vitamin D-dependent rickets type II in the differential diagnosis when rachitic changes are accompanied by alopecia.