Rickets with Alopecia: Remission Following a Course of 1-Alpha-Hydroxy Vitamin D3 Therapy

August 1989 in “ European journal of pediatrics ”

D. Manandhar, Shazwani Sarkawi, Milroy C. J. Hunt

alopecia 1-α-hydroxyvitamin D3 1-α-OH D3 vitamin D3 25-hydroxycholecalciferol parathormone 1,25-dihydroxycholecalciferol vitamin D dependent rickets type II VDDR II vitamin D dependent rickets type I VDDR I hair loss 1-α-OH D3 vitamin D3 calcifediol parathyroid hormone calcitriol VDDR II VDDR I

Studysummary This case study describes a child with rickets and alopecia who responded to a small dose of 1-a-hydroxyvitamin D3, but her alopecia remained unchanged despite treatment.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

In the 1989 study, a child with rickets and alopecia who did not improve after receiving high doses of vitamin D3 showed remission following treatment with a low dose of 1-α-hydroxyvitamin D3 (1-α-OH D3). The treatment with 1-α-OH D3 was administered for 2 years, and upon discontinuation, the child did not exhibit any signs of rickets relapse after 1 year. However, the alopecia remained unchanged. After stopping treatment, the child's serum 25-hydroxycholecalciferol and parathormone levels were normal, but serum 1,25-dihydroxycholecalciferol was elevated. This case suggests that the child's condition did not conform to the typical classification of vitamin D dependent rickets type II (VDDR II), as the good response to physiological doses of 1-α-OH D3 is more characteristic of VDDR type I. The temporary requirement for 1-α-OH D3 therapy in this case is notable, and it remains unclear whether the child would have recovered without treatment.

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Research cited in this study

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research Vitamin D-Dependent Rickets Type II: Extreme End Organ Resistance to 1,25-Dihydroxy Vitamin D3 in a Patient Without Alopecia

50 citations , October 1986 in “European journal of pediatrics”

This case study reported that absence of alopecia does not reliably predict responsiveness to vitamin D treatment in Vitamin D-dependent rickets type II, as demonstrated by a patient with normal hair growth who showed extreme resistance.

research 1,25-Dihydroxyvitamin D Resistance, Rickets, and Alopecia

110 citations , November 1984 in “The American Journal of Medicine”

This study observed that children with a genetically transmitted defect in the 1,25-dihydroxyvitamin D3 receptor experienced spontaneous healing of rickets as they aged, despite persistent mineral imbalances during treatment.

research Rickets and Alopecia with Resistance to 1,25-Dihydroxyvitamin D: Two Different Clinical Courses with Two Different Cellular Defects

88 citations , October 1983 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

In this study, distinct clinical responses and long-term resistances were observed in two pediatric patients with vitamin D-dependency type II, associated with abnormalities in their skin fibroblast interactions with 1,25-(OH)2D3.

research An Unusual Form of Vitamin D-Dependent Rickets in a Child: Alopecia and Marked End-Organ Hyposensitivity to Biologically Active Vitamin D

82 citations , October 1980 in “The Journal of Clinical Endocrinology & Metabolism”

This case study describes a child with an unusual form of vitamin D-dependent rickets, characterized by alopecia and a deficient response to active vitamin D.

research Rickets With Alopecia: An Inborn Error of Vitamin D Metabolism

170 citations , May 1979 in “The journal of pediatrics/The Journal of pediatrics”

This report describes two sisters with rickets and alopecia unresponsive to high doses of vitamin D2, where oral phosphorus supplements led to significant clinical improvement.