March 2010 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found that both epithelial and hair keratins are expressed in beard hair medulla cells, exhibiting unique patterns and interactions distinct from other hair follicle and epithelial cells.
May 2002 in “Journal of Investigative Dermatology” New findings on hair keratin, wound healing, and skin blistering were presented.
January 2026 in “Indian Journal of Ophthalmology - Case Reports” In this study, a rare case of a trichilemmal cyst in a 6-year-old's upper eyelid was observed; it was identified through histopathological examination after excision, highlighting the importance of considering trichilemmal cysts in atypical pediatric eyelid swellings.
162 citations
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December 2008 in “Stem Cells” This study found that murine vibrissa hair follicle stem cells can be differentiated into corneal epithelial-like cells in vitro using limbus-specific microenvironmental factors, suggesting a potential therapeutic source for ocular surface disorders.
June 2024 in “Current Developments in Nutrition” In this study, hydrolyzed keratin supplementation using KeraGLO® significantly improved skin parameters such as wrinkle depth, smoothness, moisture, and firmness, as well as hair health, in healthy adult females over a 90-day period at both 500mg and 1000mg doses.
March 2026 in “Institutional Repositories DataBase (IRDB)” This study observed an association between intense itching in anterior chest keloids and an increased density of nerve fibers in the epidermis, alongside elevated expression of the pruritus mediator substance P, though no difference was found in Langerhans cells related to pruritus, location, or region.
38 citations
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November 2020 in “International journal of biochemistry & cell biology” This review discusses the biological roles and diagnostic significance of keratins in mammalian colon epithelial cells and reports no new clinical results.
January 2024 in “Doria (University of Helsinki)” This study found that in mouse pancreatic β-cells, the disruption of keratin filaments due to a specific mutation in keratin 18 resulted in altered GLUT2 localization, with less GLUT2 present on the plasma membrane compared to cells with normal keratin.
68 citations
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November 2018 in “Molecular Biology and Evolution” This study found that keratin genes in the epidermis of aquatic mammals like cetaceans have evolved to replace stress-inducible keratins K1 and K10 with constitutively expressed K6 and K17, suggesting adaptations to their environment.
59 citations
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August 1981 in “PubMed” This study describes trichilemmal keratinization as a distinct process of hair follicle keratinization that occurs in specific areas of the outer root sheath, illustrated using electron microscopy on dog hair.
26 citations
,
June 2005 in “British Journal of Dermatology” Calretinin identifies the companion cell layer in human hair follicles.
73 citations
,
January 2016 in “International review of cell and molecular biology” Cornification evolved from keratinization in vertebrates, with differences between mammals and sauropsids.
85 citations
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October 2007 in “International Journal of Dermatology” In this study, researchers found that the curliness of human hair is associated with an asymmetric structure at the cellular level, particularly in the differentiation of the precortex.
January 2026 in “Annals of Pathology and Laboratory Medicine” In this case report, a 27-year-old woman with a swelling on her neck was initially misdiagnosed with squamous cell carcinoma, but was later identified as having pilomatrix carcinoma with lymph node metastasis, highlighting the importance of accurate diagnosis for effective treatment and prognosis improvement.
50 citations
,
April 2019 in “Journal of Biosciences” 19 citations
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November 2016 in “Developmental Biology”
30 citations
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April 2017 in “Journal of structural biology” This study suggests that human keratin fiber matrix has a well-defined nano-scale grainy structure rather than being amorphous, with grain size influenced by chemical treatments, temperature, humidity, and follicle-level factors.
September 2025 in “Archives of Dermatological Research” In this retrospective chart review, researchers found that keratinocyte carcinomas on the scalp and forehead of non-alopecic women occurred more frequently in the part line of the scalp, with basal cell carcinoma being more common than squamous cell carcinoma.
38 citations
,
July 1993 in “Journal of Investigative Dermatology” 9 citations
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January 2015 in “Indian Dermatology Online Journal” This case report highlights the successful treatment of Kaposi varicelliform eruption in a pemphigus vulgaris patient using intravenous acyclovir, alongside antibiotics, resulting in healing of skin lesions with scarring.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This product description promotes Kerablak Calcium Pantothenate Tablets for improving hair strength and reducing hair fall, but it provides no new clinical study findings.
December 2025 in “Journal of Clinical Medicine” In this case study, the researchers reported that surgical debridement combined with targeted dermatological and antimicrobial therapy effectively managed chronic lower-limb wounds in a patient with keratitis-ichthyosis-deafness syndrome, underscoring the importance of a multidisciplinary approach in treating this rare condition.
198 citations
,
November 1989 in “The Journal of Cell Biology” This study reported that K14 expression patterns and keratin filament organization in human skin's hair follicles differ from those in the epidermis, indicating distinct differentiation programs.
6 citations
,
January 2022 in “Gene” This study identified 53 keratins in the yak genome, predicting diverse phosphorylation sites and subcellular localizations, and highlighted strong gene expression correlations during the yak hair follicle development cycle.
7 citations
,
May 1988 in “International Journal of Dermatology” This case report describes an 18-year-old man with pili annulati, characterized by a "shagreened" appearance of the hair shaft with alternate bright and dark bands and wide holes throughout the cortex.
14 citations
,
October 2001 in “British Journal of Ophthalmology” This case report suggests a successful outcome with intralesional cidofovir for SCC, although surgical excision remains the preferred treatment.
March 2021 in “Revista da Associação Médica Brasileira”
2 citations
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December 2019 in “Cureus” This report describes a case of secondary cutis verticis gyrata due to a cerebriform intradermal nevus, highlighting clinical management and screening guidelines.
March 2026 in “The Indian Journal of Animal Sciences” This study on Indian dromedary camel breeds investigated the KRTAP7 protein, finding all four breeds shared an identical gene sequence, with 13 phosphorylation and glycosylation sites influencing hair characteristics, alongside predicted interactions with other biosynthesis-related proteins.