Beyond the Matrix: A Rare Case of Pilomatrix Carcinoma with Histologic Insights
January 2026
in “
Annals of Pathology and Laboratory Medicine
”
TLDR Accurate diagnosis of rare pilomatrix carcinoma is crucial for effective treatment.
This case report discusses a rare instance of pilomatrix carcinoma, a type of skin adnexal tumor originating from matrical cells of hair follicles, in a 27-year-old female. Initially misdiagnosed as squamous cell carcinoma, the tumor recurred and was correctly identified as pilomatrix carcinoma with regional lymph node metastasis upon re-excision. The patient is currently receiving radiotherapy due to the metastasis. The report emphasizes the importance of accurate diagnosis in improving treatment protocols and patient prognosis, given the rarity of this carcinoma.
