1 citations
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October 2021 in “Clinical, Cosmetic and Investigational Dermatology” In this study on cultured human dermal papilla cells, researchers found that niacinamide may enhance hair growth by reducing oxidative stress-induced cell senescence and delaying catagen entry, suggesting potential applications against hair loss.
July 2014 in “Journal of Dermatology and Cosmetic” This study found that topical niosomal minoxidil significantly increased hair count and patient satisfaction compared to conventional minoxidil in men with androgenetic alopecia.
2 citations
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October 2023 in “JURNAL ILMU KEFARMASIAN INDONESIA” In this study, researchers formulated a nanosuspension of kenikir leaf extract that meets physical criteria and exhibits cytotoxic activity against MCF-7 breast cancer cells.
48 citations
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July 1988 in “PubMed” In this study, researchers observed that rhino mice exhibit significant ductal hyperkeratinization in the meibomian gland, which may represent the first naturally occurring disorder of this gland in mice.
54 citations
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March 2024 in “Journal of Medicinal Chemistry” This article summarizes the properties, synthesis, and biomedical applications of molecules with N-oxide functionalities, emphasizing their growing role in healthcare due to their unique properties, such as water solubility and redox reactivity, crucial for drug targeting and cytotoxicity.
7 citations
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January 1989 Minoxidil and 4-MA can help treat hair loss.
April 2023 in “Journal of Investigative Dermatology” This study found that KROX20 is crucial for hair follicle development and epidermal homeostasis, as its deletion in skin epithelial cells led to hair loss and increased epidermal thickness.
This study found that the NuMA protein's microtubule-binding domain is essential for proper spindle orientation and differentiation in keratinocytes, affecting skin and hair development in mice.
25 citations
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January 2019 in “British Journal of Dermatology” Low oxygen levels can make hair-growing cells better at growing hair through a process involving reactive oxygen species.
3 citations
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January 2002 in “Actas Dermo-Sifiliográficas” In this case report, a 23-year-old woman developed localized trichorrhexis nodosa after compulsively applying 3% minoxidil to her scalp for two months.
April 2016 in “Journal of Investigative Dermatology” This study found a perfect correlation between laser Doppler velocimetry measurements of scalp blood perfusion after minoxidil application and sulfotransferase enzyme activity in hair follicles, indicating a potential non-invasive test to predict minoxidil response in female pattern hair loss.
November 2023 in “Animal Bioscience” This study found that miR-133a-3p and miR-145-5p influenced goat hair follicle stem cell differentiation by inhibiting NANOG expression and promoting SOX9 expression.
March 2024 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that minoxidil nanoparticles significantly increased hair growth in mice compared to commercial minoxidil and rosemary extract, demonstrating improved delivery and follicular uptake.
May 2026 in “Advanced Materials Interfaces” This study reported that a new coating made with delaminated Ti₃C₂ MXene nano-sheets and a tea-derived compound effectively protects hair keratin from damage by providing UV screening, thermal dissipation, and antioxidation, while also enhancing mechanical strength and restoring wettability.
72 citations
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December 1983 in “Journal of Investigative Dermatology” Minoxidil helps hair cells live longer and grow longer.
33 citations
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February 2021 in “Journal of Medicinal Chemistry” This study found that novel MPC inhibitor analogues with specific chemical modifications promoted significant hair growth in shaved mice when applied topically.
July 2018 in “Media Informasi” This study found that a 3:2 combination of pandan leaf and mother-in-law's tongue extracts in hair tonic showed similar hair growth activity as 5% minoxidil after three weeks.
13 citations
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June 2023 in “Frontiers in Molecular Neuroscience” This review suggests that blocking the ATP-sensitive potassium (K ATP) channel, particularly the Kir6.1/SUR2B subtype, may prove effective in treating migraines, with preclinical data supporting this approach; however, human studies are absent, and potential side effects could complicate clinical use.
7 citations
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February 2016 in “Dermatology and therapy” This study found that t-flavanone may promote hair growth in people with androgenic alopecia by enhancing hair anchoring strength and upregulating desmoglein expression in hair follicles over 30 weeks.
64 citations
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January 1995 in “Cells Tissues Organs” This study found that the development and differentiation of Merkel cells in C57BL mouse embryos' dorsolateral skin are linked to tylotrich follicle formation rather than to neural influences.
May 2015 in “Journal of The American Academy of Dermatology” Niosomal minoxidil, when applied topically, increases hair count more than conventional minoxidil solution.
This study suggests that PDRN may enhance wound healing by reducing MIR135b expression, which in turn increases FOXO1 expression in keratinocytes.
96 citations
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March 2007 in “Developmental biology” This study found that the Wnt inhibitor Dkk4 may play a role in regulating hair follicle development through a feedback loop with canonical Wnt signaling pathways.
23 citations
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February 1993 in “Journal of Investigative Dermatology” 121 citations
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December 2001 in “American Journal of Dermatopathology” This study found that trichoblastomas and nodular basal cell carcinomas have similar cytokeratin expression patterns, indicating differentiation towards the outer root sheath epithelium.
June 2024 in “International Journal of Pharmaceutical Research and Applications” This study designed fast-dissolving Minoxidil tablets to improve patient compliance and found that formulations containing 6% croscarmellose sodium were optimal, showing rapid in-vitro dispersion and effective drug release without drug interaction.
21 citations
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November 2017 in “Livestock science” This study confirms the presence of large structural variations in the genome of Nellore cattle, which may contribute to their environmental adaptation to tropical regions.
1 citations
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May 2023 in “Biochemical and Biophysical Research Communications” This study found that DKK1-targeting siRNA, which may activate the Wnt/β-catenin signaling pathway, showed hair growth results in mice similar to those treated with the FDA-approved minoxidil, suggesting potential as an androgenetic alopecia therapy.
47 citations
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September 2004 in “Journal of Biological Chemistry” This study provides evidence supporting a regulatory relationship between the transcriptional regulator Hoxc13 and Krtap16 genes, which are crucial for proper hair growth in mice.
17 citations
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January 1985 in “International Journal of Dermatology” In this study, minoxidil was found to suppress the activity of normal human T-lymphocytes in vitro, though the physiological relevance of this effect remains uncertain.