December 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” There are several promising treatments for hair loss, including dutasteride, latanoprost, ketoconazole shampoo, anti-androgens, laser/light treatment, and platelet-rich plasma, but more research is needed.
Most American men experience hair loss by age 50, with limited effective treatments available and new options not expected soon.
October 2010 in “Epilepsy Currents” This study found that inhibitory neurosteroids synthesized within glial cells can reduce seizure frequency in epileptic animals by enhancing inhibitory transmission via γ-aminobutyric acid receptors.
December 2005 in “Journal of the American Academy of Physician Assistants” The woman was diagnosed with lichen planopilaris and can be treated with corticosteroids.
January 2005 in “Farmaceutski glasnik” This review discusses various substances used in the treatment of alopecia, highlighting the roles of minoxidil and finasteride, but reports no new experimental findings.
March 2004 in “Journal of the American Academy of Dermatology” This study found that topical and intralesional corticosteroids are effective in treating the primary symptoms of lichen planopilaris and promoting hair regrowth in the active perimeter of alopecic patches.
June 2003 in “Obstetrical & Gynecological Survey” Hair loss in women can be treated with hormone therapy.
September 2002 in “Research Repository (Kingston University London)” This review discusses strategies for treating hormone-dependent prostate diseases and synthesizes a range of potential 5α-reductase inhibitors, but experimental evaluation of these compounds was not completed.
April 2002 in “Postgraduate medicine” This case report describes a 4-year-old African American boy with tinea capitis characterized by itchy, scaly patches and hair loss, diagnosed through microscopic examination after initial treatments were only partially effective.
September 1998 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” The document concludes that individualized treatments for hair issues are effective, certain hair changes can indicate neurocutaneous diseases, specific lotions improve skin health, laser hair removal works but needs more study on long-term effects, men's cosmetics are diverse, peeling is effective but can have side effects, and facial pigmentation is often due to overactive skin cells.
This study found that nisoral treatment in patients with hyperandrogenism was associated with restored menstrual cycles and reduced pathological hair growth, along with decreased testosterone and increased estradiol and progesterone levels.
This case study describes a 30-year-old woman with ACTH-independent Cushing's syndrome from adrenal carcinoma, who showed significant health improvement and normalized tests 18 months after left adrenalectomy.
July 1988 in “Journal of The American Academy of Dermatology” This article reviews therapeutic advances published between December 1986 and December 1987 but reports no new research findings; readers are advised to consult the original articles before considering new therapies.
January 1983 in “Archives of Dermatology” This case report suggests that a Penicillium species might have been the causative agent of tinea capitis in a 3-year-old boy.
March 2022 in “International journal of pharmaceutical sciences review and research” This review examines treatment options for PCOS, highlighting the importance of managing symptoms and patient counseling, and reports no new clinical results.
February 2022 in “Scientia Pharmaceutica” This study validated that six out of seven tested topical formulations for alopecia are compatible for 6-month use, suggesting they may be practical for compounding pharmacies.
March 2021 in “Berkala Ilmu Kesehatan Kulit dan Kelamin” This review discusses the treatment options for male androgenetic alopecia, including FDA-approved therapies and new possibilities, but reports no new clinical results.
Female pattern hair loss, common in women, can be treated with various methods like minoxidil, anti-androgen treatments, and light therapy, but early intervention and realistic expectations are crucial.
November 2009 in “Cambridge University Press eBooks” This review discusses the necessity for hair transplant surgeons to be well-versed in both surgical and medical treatments for various forms of alopecia, and it reports no new results.
1 citations
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January 1992 in “Juntendō Igaku/Juntendo igaku” This review discusses the hair growth mechanisms of minoxidil, suggesting both increased blood flow and a direct effect on hair follicles, but reports no new clinical results.
88 citations
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June 2019 in “Cell reports” This study found that activating autophagy with specific small molecules and drugs can stimulate hair growth by initiating the anagen phase in dormant hair follicles, suggesting a potential treatment for hair loss.
60 citations
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September 1979 in “Fertility and sterility” This study found that spironolactone reduced testosterone production and urinary 17-ketosteroid excretion, leading to a decrease in hair growth rate and a change in hair texture in women.
40 citations
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August 2018 in “Skin appendage disorders” This review examines complementary and alternative medicine for alopecia and finds limited support from robust clinical trials, highlighting the need for standardized studies to evaluate efficacy and safety.
28 citations
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March 1973 in “The Journal of Clinical Endocrinology & Metabolism” This study found that hair follicles from balding men show significant metabolic differences compared to those from non-balding individuals, particularly in their ability to process dehydroepiandrosterone.
27 citations
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May 1976 in “PubMed” This study concluded that wedge resection in patients with polycystic ovary syndrome did not significantly affect androgen status or the biochemical features of the condition, though most regained regular menstrual cycles and some became pregnant.
21 citations
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January 2003 in “Skin pharmacology and physiology” This study found that dutasteride completely suppressed the formation of 5alpha-dihydro metabolites in cultured human skin cells, suggesting its potential use in acne and androgenetic alopecia.
12 citations
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February 2020 in “The Journal of Clinical Endocrinology & Metabolism” This study found that a self-assessed modified Ferriman-Gallwey score of 10 or higher indicates excess body hair, and suggests androstenedione measurement should accompany testosterone when evaluating hyperandrogenism.
11 citations
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April 2021 in “Advanced synthesis & catalysis” This study reports that the dye peri-xanthenoxanthene (PXX) can act as an efficient photocatalyst for various radical reactions, including complex dual catalytic processes and the synthesis of an investigational drug intermediate.
9 citations
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March 2022 in “Journal of the Endocrine Society” This study found that testosterone more accurately predicts PCOS diagnosis than 11-oxyandrogens, which were linked with hirsutism severity and showed varying responses to contraceptive and metformin treatments.
9 citations
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August 1952 in “The Journal of Clinical Endocrinology & Metabolism” This study describes a method to estimate endogenous hormone production by neutralizing an endogenous hormone with an oppositely acting hormone.