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The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

The document concludes that proper diagnosis and a combination of medical, hair-care, and surgical treatments are important for managing alopecia in black women.

One minoxidil-sensitive potassium channel exists in human hair follicles.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Hair elemental analysis could be useful for health and exposure assessment but requires more standardization and research.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

CCCA is a hair loss type affecting African women, possibly caused by grooming and chemicals, with various treatments and needing more research.

Hair grays due to oxidative stress and fewer functioning melanocytes.

Advanced human skin models improve drug development and could replace animal testing.

Beta-caryophyllene helps improve wound healing in mice, especially in females.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.

Different hair care practices and conditions affect African American hair and scalp health, requiring specialized knowledge for treatment.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

Botox increased hair count in men with baldness and might work by improving scalp blood flow.

Mice lacking Insig proteins had hair growth problems due to cholesterol buildup, but this was fixed by the drug simvastatin.

Phosphatidic acid may help hair grow by affecting cell growth pathways.

Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.

Plant-based ingredients are effective and safe for modern skincare products.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Genetically-altered adult stem cells can help in wound healing and are becoming crucial in regenerative medicine and drug design.

Anthralin is effective for psoriasis and alopecia with minimal systemic side effects but can irritate the skin.

Signaling pathways are crucial for hair growth in goats.

Oral retinoids are effective for treating severe skin disorders but have reversible side effects and risks for pregnant women.

Activating NRF2 might help treat hair disorders by improving antioxidant defenses.

The 3D scaffold helped maintain hair cell traits and could improve hair loss treatments.