Assessment on the Effects of Liposome-Encapsulated Thioglycolic Acid on Hair Perming

In this study, researchers encapsulated thioglycolic acid (TGA) in liposomes using the ethanol injection method and tested 4 lipid formulations to evaluate their effects on hair perming. They found that liposomes without cholesterol had diameters between 112.5 nm and 124 nm, which increased to 288 nm to 325 nm with cholesterol. Hair treated with a pH 9.0 liposome perm solution showed a higher S-shaped wave retention (19.06% to 24.73%) after 4 washes compared to the control group (17.27%). Additionally, the cysteine content in hair treated with the liposome perm solution was higher (4.51% to 5.31%) than in the control group (4.40%). These findings indicated that liposomes improved the penetration of perm solutions into the hair cortex, enhancing the reduction of disulfide bonds.