4 citations,
January 2022 in “Life” Tissue engineering could be a future solution for hair loss, but it's currently expensive, complex, and hard to apply in real-world treatments.
3 citations,
March 2023 in “Scientific Reports” Researchers developed a new method to test hair growth drugs and found that adult cells are best for hair growth, but the method needs improvement as it didn't create mature hair follicles.
2 citations,
August 2022 in “Viruses” Skin cancer often starts from Lgr5+ progenitor cells.
December 2023 in “The journal of physical chemistry. B (1997 : Online)” Human hair keratin might be good for filtering out harmful substances from water.
January 2023 in “Theranostics” Mechanical force is important for the first contact between skin cells and hair growth in mini-organs.
December 2022 in “Scientific Reports” Stem cells from whiskers can be transplanted to stimulate hair growth.
1 citations,
April 2023 in “Journal of Animal Science and Biotechnology” Melatonin helps grow more secondary hair follicles in young goats, improving cashmere production.
6 citations,
November 2018 in “Histochemistry and Cell Biology” Mongolian gerbils heal wounds differently than mice, with unique protein levels and gene expression that affect skin repair.
1 citations,
November 2016 in “Congenital Anomalies” Get head MRI for babies with achondroplasia early, use free immunoglobulin light chains to detect certain neurodevelopmental disorders, and video calls work for speech therapy in patients with facial anomalies.
9 citations,
November 2015 in “Key Engineering Materials” Improving skills and technology in Baluchistan's wool industry could boost quality, jobs, and Pakistan's economy.
March 2015 in “Plastic and reconstructive surgery” Human skin has multiple layers and functions, with key roles in protection, temperature control, and appearance.
1 citations,
April 2023 in “Biomaterials advances” Gellan gum hydrogels help recreate the environment needed for hair growth cell function.
29 citations,
November 2011 in “Veterinary pathology” The study found that mouse sweat glands develop before birth, mature after birth, and have specific keratin patterns.
November 2016 in “Oncology Letters” Milia may come from the outer part of the hair follicle.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” The STRIPAK complex is crucial for skin cell organization and creating a functional skin barrier.
April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” CTCF protein is essential for skin and hair follicle development in mice.
25 citations,
November 2020 in “Experimental eye research/Experimental Eye Research” Different types of cells in the eye express specific keratins at various stages of development.
8 citations,
August 2014 in “Biochemical and Biophysical Research Communications” The study investigated the role of ornithine decarboxylase (ODC) in skin carcinogenesis by using genetically modified mice to direct ODC expression to specific epidermal compartments. It was found that K6-driven ODC over-expression in the outer root sheath of hair follicles significantly increased tumorigenesis compared to K14-driven ODC expression in inter-follicular epidermal keratinocytes. Mice with K6-ODC expression developed an average of 15 tumors per mouse, while K14-ODC mice developed 6.8 tumors per mouse. The K6-ODC mice also showed higher UVB-induced proliferation, pro-inflammatory responses, and a greater number of stem-like cells, with reduced Notch1 expression linked to stem cell expansion. The study concluded that ODC enhances tumorigenesis by negatively regulating the Notch pathway, leading to an expansion of the stem cell compartment.
45 citations,
December 2007 in “The FASEB journal” There are two types of stem cells in rodent hair follicles, each with different keratin proteins.
6 citations,
August 2016 in “Journal of Visualized Experiments” The CUBIC protocol allows detailed 3D visualization of proteins in mouse skin biopsies.
87 citations,
July 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” Human beard hair medulla contains a unique and complex mix of keratins not found in other human tissues.
116 citations,
August 2010 in “Nature” Scientists turned rat thymus cells into stem cells that can help repair skin and hair.
63 citations,
May 2011 in “Clinical cancer research” The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.
49 citations,
August 2004 in “The FASEB Journal” Mice with human skin protein K8 had more skin problems and cancer.
5 citations,
October 2015 in “The American journal of pathology” Mice with a mutated Dsg3 gene showed severe symptoms but not the typical blistering of pemphigus vulgaris.
5 citations,
November 2008 in “Advances in Dermatology” The review highlights the importance of stem cells in hair health and suggests new treatment strategies for hair loss conditions.
The treatment was ineffective in humans.
522 citations,
January 2001 in “Cancer investigation” Doxil is an effective, modified chemotherapy drug with a unique toxicity profile and shows promise in treating certain cancers.
242 citations,
February 2016 in “Science” Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
184 citations,
November 2014 in “Developmental Cell” Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.