21 citations
,
January 2010 in “JOURNAL OF HEALTH SCIENCE” This study found that abietic acid from pine resin more effectively inhibits testosterone 5α-reductase than several plant extracts, suggesting potential for treating androgen-dependent diseases.
86 citations
,
July 1990 in “British Journal of Pharmacology” Diazoxide, minoxidil sulphate, and cromakalim relax rat blood vessels by opening K+ channels, with some differences in their actions.
42 citations
,
January 2009 in “Colloids and Surfaces B: Biointerfaces” This study found that dimethylpabamidopropyl laurdimonium tosylate, a quaternary ammonium surfactant, adsorbs onto human scalp hair with kinetic and isotherm behaviors fitting specific models, changing hair fiber wettability from hydrophobic to hydrophilic.
8 citations
,
January 2011 in “Organic and Biomolecular Chemistry” Minoxidil reacts to nitrosation 7 times more than phenol, mainly due to its -NH₂ groups, leading to the creation of N-nitrosominoxidil.
24 citations
,
September 2005 in “Journal of Cellular Biochemistry” This study found that all-trans and 9-cis retinoic acids increase steroid sulfatase activity in HL60 cells through mechanisms involving RARα/RXR heterodimers and multiple signaling pathways.
13 citations
,
January 2012 in “International Journal of Trichology” This study reports a case where excessive consumption of "paradise nuts" led to acute selenium toxicity and massive hair loss.
71 citations
,
June 2007 in “Bioorganic & Medicinal Chemistry Letters” This study found that PLGA nanospheres improved scalp-pore permeability and enhanced hair growth activities in mice, suggesting their potential as drug delivery carriers for hair growth ingredients.
2 citations
,
January 2016 This study found that nanoemulsions containing oleic acid or eucalyptol significantly enhanced the skin penetration of caffeine and naproxen compared to aqueous solutions, primarily by increasing solute diffusivity in the stratum corneum.
January 2024 in “Journal of cutaneous and aesthetic surgery” In this clinical case report, a 10-year-old girl developed acute hair matting three weeks after scalp trauma and frequent povidone-iodine use, suggesting that scalp injuries and antiseptic overuse can be risk factors for this condition, especially when hair care is poor.
65 citations
,
April 2007 in “Chemistry and Physics of Lipids” This study found that incorporating steroid hormones into DPPC liposomes altered their physicochemical properties, including size, zeta potential, and phase transition temperatures.
12 citations
,
May 2019 in “Molecular Medicine Reports” This study demonstrated that Forsythiaside A improved survival and reduced neurological deficits in rats with cerebral ischemic injury, potentially through activating Nrf2 and reducing ER stress pathways.
13 citations
,
November 2017 in “Neurotoxicity research/Neurotoxicity resarch” This study found that sodium metabisulfite activates sodium channels and increases cellular excitability and excitotoxicity in both cardiomyocyte and neuron models, which exacerbates seizures and neuronal damage in rats.
December 2024 in “Problems of Biological Medical and Pharmaceutical Chemistry” This study examined the hair ionomic profiles of first-year RUDN University students and found distinct elemental differences between those from the Moscow region and the Middle East, suggesting these profiles may reflect the geographical and climatic conditions of their previous environments.
July 2013 in “Pharmaceutical Regulatory Affairs Open Access” Formulation F1 is the best for delivering finasteride effectively.
12 citations
,
March 2020 in “Journal of Bioactive and Compatible Polymers” This study found that finasteride- and minoxidil-loaded nanoparticles in a gel improved skin permeability and drug retention, suggesting a promising approach for topical alopecia treatment with reduced dosing frequency and side effects.
9 citations
,
April 2018 in “Journal of trace elements in medicine and biology” This review presents the practice of using hair bioelement analysis to assess nutritional status or environmental exposure, proposing complex interactions and hypotheses regarding depression and autism but reports no new clinical results.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, a chitosan-based minoxidil nanogel was developed and optimized for better scalp retention and targeted follicular delivery, showing sustained drug release over 48 hours and improved drug deposition compared to conventional minoxidil solutions.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study developed a chitosan-based nanogel for minoxidil, showing in vitro sustained drug release and higher deposition compared to conventional solutions, suggesting potential as an effective topical treatment for alopecia.
January 2026 in “MEDS Clinical Medicine” This review highlights emerging evidence that biophysical and metabolic cues, such as oxygen levels and tissue mechanics, significantly influence skin stem cell behavior, which is crucial for developing advanced wound healing therapies beyond traditional infection and inflammation control.
September 2025 in “Голова и шея.” This study examined human hair follicles exposed to different artificial media and found that Dimephosphone solution better preserved the potassium-sodium ion balance, suggesting its potential advantage for short-term graft storage compared to standard saline, which caused significant potassium "washout.
December 2023 in “Journal of molecular structure” This study found that hair membrane fluidity is low in the cuticle but high in the cortex and medulla, with treatments like ionic surfactants and oleic acid increasing fluidity in hydrated hair; however, dehydration significantly reduces fluidity throughout the hair.
This study found that nanoparticles developed with minoxidil-loaded thiolated β-cyclodextrins showed improved drug retention on hair surfaces and did not cause skin irritation in rabbits, suggesting potential for topical scalp disease treatment.
June 2023 in “Frontiers in Genetics” This study suggests that the curly hair phenotype in Mangalitza pigs may involve complex gene interactions related to calcium signaling and lipid metabolism, rather than changes in TRPM2 or CYP4F3 expression.
6 citations
,
August 2020 in “International Research Journal on Advanced Science Hub” In this study, researchers developed a niosomal gel system for transdermal delivery of testosterone, reporting strong penetrative capability, good spreadability, and a promising in vitro drug release profile, suggesting it may be an effective alternative for reducing the side effects of steroid treatments.
6 citations
,
September 2013 in “Advanced materials research” This study found that non-ionic silicone emulsion best protected hair color from UV-induced fading, outperforming honeysuckle extract and benzophenone-3, with significant effects in both dyed and virgin hair.
3 citations
,
January 2002 in “Springer eBooks” This study found that using cationic and non-ionic polymers during alkaline hair relaxer treatments may help strengthen hair and control swelling, potentially reducing damage.
1 citations
,
July 2017 in “Global journal of pharmacy & pharmaceutical sciences” The study explored niosome formulations containing minoxidil and tretinoin and found increased drug stability and controlled release, suggesting potential as an effective drug delivery system for treating hair loss.
January 2023 in “Records of Pharmaceutical and Biomedical Sciences” This review discusses the advantages and properties of mucoadhesive buccal dosage forms and reports no new clinical findings; the authors emphasize the potential of spanlastics as flexible, biodegradable drug carriers.
13 citations
,
January 2002 in “Biological chemistry” This study found that hair follicle-specific keratins can form different structural assemblies depending on ionic conditions, with hair cortex keratins requiring physiological salt conditions to form intermediate filaments.
40 citations
,
August 2014 in “Journal of Nanoparticle Research” This study found that biologically synthesized silver nanoparticle gel demonstrated excellent wound healing efficacy in rats, surpassing both marketed formulations and ionic silver.