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    Glossary Interferon Signature

    specific gene expression pattern induced by immune proteins

    The term "Interferon Signature" refers to a specific pattern of gene expression that is induced by interferons, which are proteins that play a crucial role in the immune response against viruses and other pathogens. This signature can be detected in various tissues and is often used as a biomarker to diagnose and monitor autoimmune diseases, infections, and certain types of cancer.

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    1. Type 1 interferon signature in the scalp lesions of alopecia areata British Journal of Dermatology · 2010 · 52 citations
    2. Type 1 interferon signature and cytotoxic T lymphocyte activation targeted against sweat ducts in inflammatory acquired idiopathic generalized anhidrosis Journal of the European Academy of Dermatology and Venereology · 2023 · 6 citations
    3. Epidermal γδ T cells, CD8 T cells and macrophages are increased in number in alopecia areata and express BST2 as part of an interferon-driven antiviral gene signature bioRxiv (Cold Spring Harbor Laboratory) · 2025
    4. Plucked hair follicles from patients with chronic discoid lupus erythematosus show a disease-specific molecular signature Lupus Science & Medicine · 2019 · 17 citations
    5. Developing human fetal skin demonstrates a unique lymphocyte signature bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 1 citations
    6. Immune signatures of psoriasis: Comparison of genetic expression profiles in psoriasis patients after therapy with biologic agents Journal of The American Academy of Dermatology · 2015
    7. Circulating MicroRNA Signatures in Severe Alopecia Areata: Diagnostic Discrimination, Pathway Analysis, and Therapeutic Implications Preprints.org · 2025
    8. Identification of Distinct Immune Signatures and Chemokine Networks in Scalp Inflammatory Diseases Research Square (Research Square) · 2023
    9. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015 · 184 citations
    10. Novel TMEM173 Mutation and the Role of Disease Modifying Alleles Frontiers in immunology · 2019 · 47 citations
    11. Characterization of novel TMEM173 mutation with additive IFIH1 risk allele bioRxiv (Cold Spring Harbor Laboratory) · 2018 · 1 citations
    12. 034 Characterization of novel TMEM173 mutation causing a lupus- and SAVI-like phenotype, modified by polymorphisms in TMEM173 and IFIH1 2019
    13. Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders Frontiers in Immunology · 2020 · 20 citations
    14. FilaggrinHigh melanomas exhibit active FGFR and allergic signatures with impaired GNA14 and Th1 signatures Frontiers in Genetics · 2025 · 1 citations
    15. Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid LupusErythematosus by Weighted Gene Co-Expression Network Analysis Research Square (Research Square) · 2022
    16. T <sub>H</sub> 1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata Science Advances · 2025
    17. Table 1_A meta-analysis of chemokines in alopecia areata: recruiting immune cells toward the hair follicle.docx Figshare · 2025
    18. 854 CCL5 affects the hair-inductive capacity of three-dimensional (3D)-cultured dermal papilla cells Journal of Investigative Dermatology · 2017 · 1 citations
    19. Rapid skin repigmentation on oral ruxolitinib in a patient with coexistent vitiligo and alopecia areata (AA) Journal of the American Academy of Dermatology · 2015 · 157 citations
    20. Treatment of an alopecia areata patient with tofacitinib results in regrowth of hair and changes in serum and skin biomarkers Experimental Dermatology · 2016 · 70 citations
    21. 1616 Cross-comparison of inflammatory skin disease transcriptomics identifies PTEN as a pathogenic disease classifier in cutaneous lupus erythematosus Journal of Investigative Dermatology · 2023
    22. TYK2 Inhibition with Deucravacitinib Improves Clinical Outcomes and Resolves Interferon-Driven Inflammation in Lichen Planopilaris 2026
    23. Circulating MicroRNA Signatures in Severe Alopecia Areata: Diagnostic Discrimination, Pathway Analysis, and Therapeutic Implications Dermatology and Therapy · 2026
    24. Early prediction of alopecia areata using machine learning modeling of neuro stress immune signatures from multi datasets Scientific Reports · 2025 · 1 citations
    25. CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata Journal of Immunology · 2016 · 64 citations
    26. Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery BMC Genomics · 2024 · 9 citations
    27. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018 · 80 citations
    28. The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1 New England Journal of Medicine · 2024 · 71 citations
    29. Dengue Virus Infects Primary Human Hair Follicle Dermal Papilla Cells Frontiers in Cellular and Infection Microbiology · 2018 · 14 citations
    30. Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles International Journal of Molecular Sciences · 2014 · 11 citations